Kaspaza-11

Izvor: Wikipedia
Kaspaza-11
Identifikatori
EC broj 3.4.22.64
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Kaspaza-11 (EC 3.4.22.64, CASP-11) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence (Ile/Leu/Val/Phe)-Gly-His-Asp-

Ovaj murinski enzim je deo familije inflamatornih kaspaza, u koji se takođe ubrajaju kaspaza-1 (EC 3.4.22.36), kaspaza-4 (EC 3.4.22.57) i kaspaza-5 (EC 3.4.22.58) kod ljudi i kaspaza-12, kaspaza-13 i kaspaza-14 kod miševa.

Reference[uredi - уреди]

  1. Kang, S.J., Wang, S., Hara, H., Peterson, E.P., Namura, S., Amin-Hanjani, S., Huang, Z., Srinivasan, A., Tomaselli, K.J., Thornberry, N.A., Moskowitz, M.A. and Yuan, J. (2000). "Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions". J. Cell. Biol. 149: 613–622. PMID 10791975. 
  2. Hur, J., Kim, S.Y., Kim, H., Cha, S., Lee, M.S. and Suk, K. (2001). "Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway". FEBS Lett. 507: 157–162. PMID 11684090. 
  3. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E. and Yuan, J. (1998). "Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE". Cell 92: 501–509. PMID 9491891. 
  4. Endo, M., Mori, M., Akira, S. and Gotoh, T. (2006). "C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation". J. Immunol. 176: 6245–6253. PMID 16670335. 
  5. Chang, H.Y. and Yang, X. (2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiol. Mol. Biol. Rev. 64: 821–846. PMID 11104820. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]