Kaspaza-5

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(Preusmjereno sa stranice EC 3.4.22.58)
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Kaspaza-5
Identifikatori
EC broj 3.4.22.58
CAS broj 192465-11-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Kaspaza-5 (EC 3.4.22.58, ICErel-III, Ich-3, ICH-3 proteaza, transkript Y, TY, CASP-5) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Tyr-Val-Ala-Asp- ali se takođe razlaže Asp-Glu-Val-Asp-

Ovaj enzim pripada familiji inflamatornih kaspaza, koja takođe obuhvata kaspazu-1 (EC 3.4.22.36) i kaspazu-4 (EC 3.4.22.57) kod ljudi i kaspazu-11 (EC 3.4.22.64), kaspazu-12, kaspazu-13 i kaspazu-14 kod miševa.

Reference[uredi | uredi kod]

  1. Faucheu, C., Blanchet, A.M., Collard-Dutilleul, V., Lalanne, J.L. and Diu-Hercend, A. (1996). „Identification of a cysteine protease closely related to interleukin-1 β-converting enzyme”. Eur. J. Biochem. 236: 207-213. PMID 8617266. 
  2. Kamada, S., Funahashi, Y. and Tsujimoto, Y. (1997). „Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases”. Cell Death Differ. 4: 473-478. PMID 16465268. 
  3. Lin, X.Y., Choi, M.S. and Porter, A.G. (2000). „Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-γ”. J. Biol. Chem. 275: 39920-39926. PMID 10986288. 
  4. Fassy, F., Krebs, O., Rey, H., Komara, B., Gillard, C., Capdevila, C., Yea, C., Faucheu, C., Blanchet, A.M., Miossec, C. and Diu-Hercend, A. (1998). „Enzymatic activity of two caspases related to interleukin-1β-converting enzyme”. Eur. J. Biochem. 253: 76-83. PMID 9578463. 
  5. Martinon, F. and Tschopp, J. (2004). „Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases”. Cell 117: 561-574. PMID 15163405. 
  6. Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820. 

Literatura[uredi | uredi kod]

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