Indapamid
Prijeđi na navigaciju
Prijeđi na pretragu
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 4-hloro-N-(2-metil-2,3-dihidro-1Hindol-1-il)-3-sulfamoilbenzamid | |||
| Klinički podaci | |||
| Robne marke | Apo-Indapamide, Arifon, Bajaten, Cormil | ||
| AHFS/Drugs.com | Monografija | ||
| Identifikatori | |||
| CAS broj | 26807-65-8 | ||
| ATC kod | C03BA11 | ||
| PubChem[1][2] | 3702 | ||
| DrugBank | DB00808 | ||
| ChemSpider[3] | 3574 | ||
| Hemijski podaci | |||
| Formula | C16H16ClN3O3S | ||
| Mol. masa | 365.835 | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Fizički podaci | |||
| Tačka topljenja | 161 °C (322 °F) | ||
| Farmakokinetički podaci | |||
| Poluvreme eliminacije | 14 sati | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
| Način primene | Oralno | ||
Indapamid je benzamid-sulfonamid-indol. On je tiazidu sličan diureti, mada ne sadrži tiazidni prsten. Koristi se za tretiranje hipertenzije, kao i dekompenzovane srčane insuficijencije. On je u prodaji pod imenom Lozol.[4][5][6][7]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Lozol
- ↑ Dong DL, Wang QH, Yue P, Jiao JD, Gu RM, Yang BF: Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. Eur J Pharmacol. 2006 Apr 24;536(1-2):78-84. Epub 2006 Mar 2. PMID 16556441
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
