Gama-glutamilna hidrolaza

Izvor: Wikipedia
Gama-glutamilna hidrolaza
Identifikatori
EC broj 3.4.19.9
CAS broj 9074-87-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Gama-glutamilna hidrolaza (EC 3.4.19.9, konjugaza, folatna konjugaza, lizozomalna gama-glutamilna karboksipeptidaza, gama-Glu-X karboksipeptidaza, pteroil-poli-gama-glutamatna hidrolaza, karboksipeptidaza G, folno kiselinska konjugaza, poli(gama-glutaminsko kiselinska) endohidrolaza, poliglutamatna hidrolaza, poli(glutaminsko kiselinska) hidrolaza II, pteroilpoli-gama-glutamilna hidrolaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza gama-glutamilne veze

Ova lizozomalna ili izlučena, tiol-zavisna peptidaza je najaktivnija na kiselom pH.

Reference[uredi - уреди]

  1. McGuire, J.J. and Coward, J.K. (1984). "Pteroylpolyglutamates: biosynthesis, degradation and function.". u: Blakley, R.L. and Benkovic, S.J.. Folates and Pterins. New York: John Wiley and Sons. str. 135-191. 
  2. Wang, Y., Nimec, Z., Ryan, T.J., Dias, J.A. and Galivan, J. (1993). "The properties of the secreted γ-glutamyl hydrolases from H35 hepatoma cells". Biochim. Biophys. Acta 1164: 227–235. PMID 8343522. 
  3. Yao, R., Rhee, M.S. and Galivan, J. (1995). "Effects of γ-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells". Mol. Pharmacol. 48: 505–511. PMID 7565632. 
  4. Yao, R., Schneider, E., Ryan, T.J. and Galivan, J. (1996). "Human γ-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro". Proc. Natl. Acad. Sci. USA 93: 10134–10138. PMID 8816764. 
  5. Yao, R., Nimec, Z., Ryan, T.J. and Galivan, J. (1996). "Identification, cloning, and sequencing of a cDNA coding for rat γ-glutamyl hydrolase". J. Biol. Chem. 271: 8525–8528. PMID 8621474. 

Literatura[uredi - уреди]

  • McGuire, J.J. and Coward, J.K. (1984). "Pteroylpolyglutamates: biosynthesis, degradation and function.". u: Blakley, R.L. and Benkovic, S.J.. Folates and Pterins. New York: John Wiley and Sons. str. 135-191. 

Spoljašnje veze[uredi - уреди]