Gama-D-glutamil-meso-diaminopimelatna peptidaza
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| Gama-D-glutamil-meso-diaminopimelatna peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.11 | ||||||||
| CAS broj | 62572-28-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Gama-D-glutamil-meso-diaminopimelatna peptidaza (EC 3.4.19.11, endopeptidaza I, gama-D-glutamildiaminopimelatna endopeptidaza, gama-D-glutamil-L-meso-diaminopimelatna peptidoglikanska hidrolaza, gama-glutamil-L-meso-diaminopimelilna endopeptidaza, gama-D-glutamil-meso-diaminopimelatna endopeptidaza, gama-D-glutamil-meso-diaminopimelinska peptidoglikanska hidrolaza, gama-D-glutamil-meso-diaminopimelinska endopeptidaza, gama-D-glutamil-meso-D-aminopimelinska endopeptidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza gama-D-glutamilnih veza do L-terminusa (pozicije 7) meso-diaminopimelinske kiselina (meso-A2pm) in 7-(L-Ala-gama-D-Glu)-meso-A2pm i 7-(L-Ala-gama-D-Glu)-7-(D-Ala)-meso-A2pm. Neophodno je da D-terminalne amino i karboksi grupe meso-A2pm nisu supstituisane
Ova metalopeptidaza je izolovana iz bakterije Bacillus sphaericus.
Reference[uredi | uredi kod]
- ↑ Arminjon, F., Guinand, M., Vacheron, M.-J. and Michel, G. (1977). „Specificity profiles of the membrane-bound γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602”. Eur. J. Biochem. 73: 557-565. PMID 849747.
- ↑ Garnier, M., Vacheron, M.-J., Guinard, M. and Michel, G. (1985). „Purification and partial characterization of the extracellular γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602”. Eur. J. Biochem. 148: 539-543. PMID 3922755.
- ↑ Hourdou, M.-L., Guinand, M., Vacheron, M.-J., Michel, G., Denoroy, L., Duez, C., Englebert, S., Joris, B., Weber, G. and Ghuysen, J.-M. (1993). „Characterization of the sporulation-related γ-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein”. Biochem. J. 292: 563-570. PMID 8503890.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.