Citozol-alanilna aminopeptidaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Citozol-alanilna aminopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.14 | ||||||||
| CAS broj | 243859-94-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Citozol-alanilna aminopeptidaza (EC 3.4.11.14, arilamidaza, aminopolipeptidaza, tiol-aktivirana aminopeptidaza, aminopeptidaza ljudske jetre, puromicin-senzitivna aminopeptidaza, aminopeptidaza rastvornog alanila, citosolna aminopeptidaza III, alaninska aminopeptidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje N-terminalne aminokiseline, preferentno alanina, sa širokog opsega peptida, amida i arilamida
Ovaj enzim je senzitivan na puromicin. Za njegov rad je neophodan jon Co2+.
Reference[uredi | uredi kod]
- ↑ Starnes, W.L. and Behal, F.J. (1974). „A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein”. Biochemistry 13: 3221-3227. PMID 4841062.
- ↑ Kao, Y.J., Starnes, W.L. and Behal, F.J. (1978). „Human kidney alanine aminopeptidase: physical and kinetic properties of a sialic acid containing glycoprotein”. Biochemistry 17: 2990-2994. PMID 698181.
- ↑ Sidorowicz, W., Hsia, W.-C., Maslej-Zownir, M. and Behal, F.J. (1980). „Multiple molecular forms of human alanine aminopeptidase: imunochemical properties”. Clin. Chim. Acta 107: 245-256. PMID 6108169.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.