CDP-4-dehidro-6-dezoksiglukoza reduktaza
| CDP-4-dehidro-6-dezoksiglukoza reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.1.1 | ||||||||
| CAS broj | 37256-87-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
CDP-4-dehidro-6-dezoksiglukoza reduktaza (EC 1.17.1.1, CDP-4-keto-6-dezoksiglukoza reduktaza, citidin difosfo-4-keto-6-dezoksi-D-glukozna reduktaza, citidin difosfat 4-keto-6-dezoksi-D-glukozna 3-dehidrogenaza, CDP-4-keto-dezoksi-glukozna reduktaza, CDP-4-keto-6-dezoksi-D-glukoza-3-dehidrogenazna sistem, NAD(P)H:CDP-4-keto-6-dezoksi-D-glukozna oksidoreduktaza) je enzim sa sistematskim imenom CDP-4-dehidro-3,6-didezoksi-D-glukoza:NAD(P)+ 3-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CDP-4-dehidro-3,6-didezoksi-D-glukoza + NAD(P)+ + H2O CDP-4-dehidro-6-dezoksi-D-glukoza + NAD(P)H + H+
Ovaj enzim se sastoji od dva proteina. Jedan formira enzim-vezani dodatak CDP-4-dehidro-6-dezoksiglukoze sa piridoksamin fosfatom, u kome je 3-hidroksi grupa uklonjena. Drugi katalizuje redukciju ovog adukta putem NAD(P)H i otpuštanje CDP-4-dehidro-3,6-didezoksi-D-glukoze i piridoksamin fosfata.
Reference[uredi | uredi kod]
- ↑ Pape, H. and Strominger, J.L. (1969). „Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V. Partial purification of the two protein components required for introduction of the 3-deoxy group”. J. Biol. Chem. 244: 3598-3604. PMID 4389672.
- ↑ Rubenstein, P.A. and Strominger, J.L. (1974). „Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. VII. Mechanistic roles of enzyme E1 and pyridoxamine 5′-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose”. J. Biol. Chem. 249: 3776-3781. PMID 4152100.
- ↑ Liu, H.-W. and Thorson, J.S. (1994). „Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria”. Annu. Rev. Microbiol. 48: 223-256. PMID 7826006.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.