Arestin beta 2

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Arestin beta 2
Identifikatori
Simboli ARRB2; ARB2; ARR2; DKFZp686L0365
Vanjski ID OMIM107941 MGI99474 HomoloGene3183 GeneCards: ARRB2 Gene
Pregled RNK izražavanja
PBB GE ARRB2 203388 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 409 216869
Ensembl ENSG00000141480 ENSMUSG00000060216
UniProt P32121 Q3UCU5
RefSeq (mRNA) NM_004313 XM_993633
RefSeq (protein) NP_004304 XP_998727
Lokacija (UCSC) Chr 17:
4.56 - 4.57 Mb
Chr 11:
70.25 - 70.26 Mb
PubMed pretraga [1] [2]

Arestin beta 2 (Beta arestin 2) je intracelularni protein koji je kod čoveka kodiran ARRB2 genom.

Za članove arestin/beta-arestin proteinske familije se smatra da učestvuju u agonistom-posredovanoj desenzitizaciji G protein-spregnutih receptora i izazivaju specifično prigušenje ćelijskog odgovora na stimuluse kao što su hormoni, neurotransmiteri, ili senzorne signale,[1][2][3] kao i da imaju zasebne signalne uloge.[4][5][6][7][8] Za arestin beta 2, poput arestina beta 1, je pokazano da inhibira funkciju beta-adrenergičkog receptora in vitro. On je izražen u visokim nivoima u centralnom nervnom sistemu i učestvuje u regulaciji sinaptičkih receptora. Pored mozga, cDNK za arestin beta 2 je bila izolovana iz tiroidne žlezde, i stoga on možda učestvuje u hormon-specifičnoj desenzitizaciji TSH receptora. Više alternativno splajsovanih transkriptnih varijanti ovog gena je nađeno.[9]

Ovaj protein može da interaguje sa agonistom DOI u signalizaciji 5-HT2A receptora.[10][11]

Interakcije[uredi - уреди]

Za arestin beta 2 je pokazano da interaguje sa

Literatura[uredi - уреди]

  1. Breivogel CS, Lambert JM, Gerfin S, Huffman JW, Razdan RK (July 2008). "Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice". Behavioural Pharmacology 19 (4): 298–307. doi:10.1097/FBP.0b013e328308f1e6. PMC 2751575. PMID 18622177. 
  2. Li Y, Liu X, Liu C, Kang J, Yang J, Pei G, Wu C (March 2009). "Improvement of Morphine-Mediated Analgesia by Inhibition of beta-Arrestin 2 Expression in Mice Periaqueductal Gray Matter". International Journal of Molecular Sciences 10 (3): 954–63. doi:10.3390/ijms10030954. PMC 2672012. PMID 19399231. 
  3. Zheng H, Loh HH, Law PY (January 2008). "Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation". Molecular Pharmacology 73 (1): 178–90. doi:10.1124/mol.107.039842. PMC 2253657. PMID 17947509. 
  4. Ma L, Pei G (January 2007). "Beta-arrestin signaling and regulation of transcription". Journal of Cell Science 120 (Pt 2): 213–8. doi:10.1242/jcs.03338. PMID 17215450. 
  5. Defea K (March 2008). "Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction". British Journal of Pharmacology. 153 Suppl 1: S298–309. doi:10.1038/sj.bjp.0707508. PMC 2268080. PMID 18037927. 
  6. Barki-Harrington L, Rockman HA (February 2008). "Beta-arrestins: multifunctional cellular mediators". Physiology (Bethesda, Md.) 23: 17–22. doi:10.1152/physiol.00042.2007. PMID 18268361. 
  7. Patel PA, Tilley DG, Rockman HA (March 2009). "Physiologic and cardiac roles of beta-arrestins". Journal of Molecular and Cellular Cardiology 46 (3): 300–8. doi:10.1016/j.yjmcc.2008.11.015. PMID 19103204. 
  8. Golan M, Schreiber G, Avissar S (2009). "Antidepressants, beta-arrestins and GRKs: from regulation of signal desensitization to intracellular multifunctional adaptor functions". Current Pharmaceutical Design 15 (14): 1699–708. doi:10.2174/138161209788168038. PMID 19442183. 
  9. "Entrez Gene: ARRB2 arrestin, beta 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=409. 
  10. Schmid CL, Raehal KM, Bohn LM (January 2008). "Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo". Proc. Natl. Acad. Sci. U.S.A. 105 (3): 1079–84. doi:10.1073/pnas.0708862105. PMC 2242710. PMID 18195357. 
  11. Abbas A, Roth BL (January 2008). "Arresting serotonin". Proc. Natl. Acad. Sci. U.S.A. 105 (3): 831–2. doi:10.1073/pnas.0711335105. PMC 2242676. PMID 18195368. 
  12. Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, Caron MG, Barak LS (March 1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. doi:10.1073/pnas.96.7.3712. PMC 22359. PMID 10097102. 
  13. Kim YM, Benovic JL (August 2002). "Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking". J. Biol. Chem. 277 (34): 30760–8. doi:10.1074/jbc.M204528200. PMID 12070169. 
  14. Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ (November 2001). "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45): 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043. 
  15. Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G (February 2003). "Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2". J. Biol. Chem. 278 (8): 6363–70. doi:10.1074/jbc.M210350200. PMID 12488444. 
  16. Wang P, Wu Y, Ge X, Ma L, Pei G (March 2003). "Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus". J. Biol. Chem. 278 (13): 11648–53. doi:10.1074/jbc.M208109200. PMID 12538596. 
  17. Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM (August 2008). "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor". J. Biol. Chem. 283 (32): 22166–76. doi:10.1074/jbc.M709668200. PMC 2494938. PMID 18544533. 
  18. Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nat. Cell Biol. 4 (8): 547–55. doi:10.1038/ncb821. PMID 12105416. 

Dodatna literatura[uredi - уреди]

  • Lefkowitz RJ (1998). "G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.". J. Biol. Chem. 273 (30): 18677–80. doi:10.1074/jbc.273.30.18677. PMID 9668034. 
  • Attramadal H, Arriza JL, Aoki C, et al. (1992). "Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.". J. Biol. Chem. 267 (25): 17882–90. PMID 1517224. 
  • Rapoport B, Kaufman KD, Chazenbalk GD (1992). "Cloning of a member of the arrestin family from a human thyroid cDNA library.". Mol. Cell. Endocrinol. 84 (3): R39–43. doi:10.1016/0303-7207(92)90038-8. PMID 1587386. 
  • Calabrese G, Sallese M, Stornaiuolo A, et al. (1995). "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes.". Genomics 23 (1): 286–8. doi:10.1006/geno.1994.1497. PMID 7695743. 
  • Parruti G, Peracchia F, Sallese M, et al. (1993). "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.". J. Biol. Chem. 268 (13): 9753–61. PMID 8486659. 
  • Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.". FEBS Lett. 402 (2-3): 203–8. doi:10.1016/S0014-5793(96)01531-1. PMID 9037196. 
  • Barak LS, Ferguson SS, Zhang J, Caron MG (1997). "A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.". J. Biol. Chem. 272 (44): 27497–500. doi:10.1074/jbc.272.44.27497. PMID 9346876. 
  • Laporte SA, Oakley RH, Zhang J, et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. doi:10.1073/pnas.96.7.3712. PMC 22359. PMID 10097102. 
  • Cheng ZJ, Zhao J, Sun Y, et al. (2000). "beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.". J. Biol. Chem. 275 (4): 2479–85. doi:10.1074/jbc.275.4.2479. PMID 10644702. 
  • Lin F, Wang H, Malbon CC (2000). "Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization.". J. Biol. Chem. 275 (25): 19025–34. doi:10.1074/jbc.275.25.19025. PMID 10858453. 
  • McDonald PH, Chow CW, Miller WE, et al. (2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.". Science 290 (5496): 1574–7. doi:10.1126/science.290.5496.1574. PMID 11090355. 
  • Luttrell LM, Roudabush FL, Choy EW, et al. (2001). "Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2449–54. doi:10.1073/pnas.041604898. PMC 30158. PMID 11226259. 
  • Cen B, Yu Q, Guo J, et al. (2001). "Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor.". J. Neurochem. 76 (6): 1887–94. doi:10.1046/j.1471-4159.2001.00204.x. PMID 11259507. 
  • Oakley RH, Laporte SA, Holt JA, et al. (2001). "Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.". J. Biol. Chem. 276 (22): 19452–60. doi:10.1074/jbc.M101450200. PMID 11279203. 
  • Miller WE, McDonald PH, Cai SF, et al. (2001). "Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.". J. Biol. Chem. 276 (30): 27770–7. doi:10.1074/jbc.M102264200. PMID 11356842. 
  • Claing A, Chen W, Miller WE, et al. (2001). "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.". J. Biol. Chem. 276 (45): 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043. 
  • Hilairet S, Bélanger C, Bertrand J, et al. (2001). "Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin.". J. Biol. Chem. 276 (45): 42182–90. doi:10.1074/jbc.M107323200. PMID 11535606. 
  • Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001). "Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.". Science 294 (5545): 1307–13. doi:10.1126/science.1063866. PMID 11588219. 
  • Chen Z, Dupré DJ, Le Gouill C, et al. (2002). "Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif.". J. Biol. Chem. 277 (9): 7356–62. doi:10.1074/jbc.M110058200. PMID 11729201.