Alken monooksigenaza
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| Alken monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.69 | ||||||||
| CAS broj | 63439-50-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Alken monooksigenaza (EC 1.14.13.69, alkenska epoksigenaza) je enzim sa sistematskim imenom alken,NADH:kiseonik oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- propen + NADH + H+ + O2 1,2-epoksipropan + NAD+ + H2O
Enzim iz Xanthobacter sp. vrste Py2 je multikomponentni enzim koji sadrži (1) NADH reduktazu, koja pruža reduktant za O2 aktivaciju; (2) feredoksina Riskijevog tipa, koji je protein elektronskog transfera; (3) oksigenazu, koja sadrži katalitički centar za alkensku epoksidaciju i (4) malog proteina nepoznate funkcije koji je esencijalan za aktivnost.
Reference[uredi | uredi kod]
- ↑ Small, F.J. and Ensign, S.A. (1997). „Alkene monooxygenase from Xanthobacter strain Py2: purification and characterization of a four-component system central to the bacterial metabolism of aliphatic alkenes”. J. Biol. Chem. 272: 24913-24920. PMID 9312093.
- ↑ Zhou, N.Y., Jenkins, A., Chion, C.K.N.C.K. and Leak, D.J. (1999). „The alkene monooxygenase from Xanthobacter strain Py2 is closely related to aromatic monooxygenases and catalyzes aromatic monohydroxylation of benzene, toluene, and phenol”. Appl. Environ. Microbiol. 65: 1589-1595. PMID 10103255.
- ↑ Gallagher, S.C., Cammack, R. and Dalton, H. (1997). „Alkene monooxygenase from Nocardia corallina B-276 is a member of the class of dinuclear iron proteins capable of stereospecific epoxygenation reactions”. Eur. J. Biochem. 247: 635-641. PMID 9266707.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.