2-(acetamidometiln)sukcinatna hidrolaza
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| 2-(acetamidometiln)sukcinatna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.29 | ||||||||
| CAS broj | 37289-09-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-(acetamidometiln)sukcinatna hidrolaza (EC 3.5.1.29, alfa-(N-acetilaminometilin)sukcinsko kiselinska hidrolaza) je enzim sa sistematskim imenom 2-(acetamidometilin)sukcinat amidohidrolaza (deaminacija, dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-(acetamidometilin)sukcinat + 2H2O acetat + sukcinat semialdehid + NH3 + CO2
Ovaj enzim učestvuje u degradaciji piridoksina u Pseudomonas.
Reference[uredi | uredi kod]
- ↑ Huynh, M.S. and Snell, E.E. (1985). „Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases”. J. Biol. Chem. 260: 2379-2383. PMID 3972793.
- ↑ Nyns, E.J., Zach, D. and Snell, E.E. (1969). „The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of α-(N-acetylaminomethylene) succinic acid”. J. Biol. Chem. 244: 2601-2605. PMID 5769993.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.