1-pirolidin dehidrogenaza
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| 1-pirolidin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.1.35 | ||||||||
| CAS broj | 9054-82-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
1-pirolidin dehidrogenaza (EC 1.5.1.35, gama-aminobutiraldehidna dehidrogenaza, ABALDH, YdcW) je enzim sa sistematskim imenom 1-pirolidin:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-pirolidin + NAD+ + 2H2O 4-aminobutanoat + NADH + 2 H+
1-pirolidin se spontano formira iz 4-aminobutanala, posredstvom enzima EC 2.6.1.82, putrescin aminotransferaze. Ovaj enzim formira deo puta argininskog katabolizma.
Reference[uredi | uredi kod]
- ↑ Prieto-Santos, M.I., Martin-Checa, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1986). „A pathway for putrescine catabolism in Escherichia coli”. Biochim. Biophys. Acta 880: 242-244. PMID 3510672.
- ↑ Prieto, M.I., Martin, J., Balaña-Fouce, R. and Garrido-Pertierra, A. (1987). „Properties of γ-aminobutyraldehyde dehydrogenase from Escherichia coli”. Biochimie 69: 1161-1168. PMID 3129020.
- ↑ Samsonova, N.N., Smirnov, S.V., Novikova, A.E. and Ptitsyn, L.R. (2005). „Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase”. FEBS Lett. 579: 4107-4112. PMID 16023116.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.