Inozin monofosfatna sintaza

5-Aminoimidazol-4-karboksamid ribonukleotid formiltransferaza/IMP ciklohidrolaza
	; PDB prikaz baziran na 1p4r
Dostupne strukture
	1P4R, 1PKX, 1PL0
Identifikatori
Simboli	ATIC; AICAR; AICARFT; IMPCHASE; PURH
Vanjski ID	OMIM: 601731 MGI: 1351352 HomoloGene: 2983 GeneCards: ATIC Gene
EC broj	3.5.4.10 2.1.2.3, 3.5.4.10
Ontologija gena
Molekularna funkcija	• IMP ciklohidrolazna aktivnost; • fosForibozilaminoimidazolkarboksamid formiltransferazna aktivnost; • proteinska homodimerizaciona aktivnost;
Celularna komponenta	• mitohondrija; • citozol;
Biološki proces	• nujleobazni metabolički proces; • purinski nukleobazni metabolički proces; • 'de novo' IMP biosintetički proces;
Pregled RNK izražavanja
	podaci
Ortolozi

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Bifunkcionalni purinski biosintetički protein PURH je protein koji je kod čoveka kodiran ATIC genom.^[1]^[2]^[3]

ATIC kodira enzim koji generiše inozin monofosfat iz aminoimidazol karboksamid ribonukleotida.

On ima dve funkcije:

Reference

↑ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). „The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping”. J Biol Chem 271 (4): 2225–33. DOI:10.1074/jbc.271.4.2225. PMID 8567683.
↑ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). „Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase”. J Biochem 122 (2): 309–13. PMID 9378707.
↑ „Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase”.

Literatura

Rasmussen HH, van Damme J, Puype M i dr.. (1993). „Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes”. Electrophoresis 13 (12): 960–9. DOI:10.1002/elps.11501301199. PMID 1286667.
Yamauchi M, Seki N, Mita K i dr.. (1996). „Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript”. DNA Res. 2 (6): 269–75. DOI:10.1093/dnares/2.6.269. PMID 8867801.
Beardsley GP, Rayl EA, Gunn K i dr.. (1998). „Structure and functional relationships in human pur H”. Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 431: 221–6. DOI:10.1007/978-1-4615-5381-6_43. ISBN 978-0-306-45778-4. PMID 9598063.
Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). „Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity”. J. Biol. Chem. 276 (11): 7727–33. DOI:10.1074/jbc.M009940200. PMID 11096114.
Bulock KG, Beardsley GP, Anderson KS (2002). „The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling”. J. Biol. Chem. 277 (25): 22168–74. DOI:10.1074/jbc.M111964200. PMID 11948179.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cheong CG, Wolan DW, Greasley SE i dr.. (2004). „Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates”. J. Biol. Chem. 279 (17): 18034–45. DOI:10.1074/jbc.M313691200. PMID 14966129.
Marie S, Heron B, Bitoun P i dr.. (2004). „AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC”. Am. J. Hum. Genet. 74 (6): 1276–81. DOI:10.1086/421475. PMC 1182092. PMID 15114530.
Dervieux T, Furst D, Lein DO i dr.. (2004). „Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis”. Arthritis Rheum. 50 (9): 2766–74. DOI:10.1002/art.20460. PMID 15457444.
Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F i dr.. (2007). „Large-scale mapping of human protein–protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Spoljašnje veze

MeSH Inosine+monophosphate+synthase

[pmid8567683-1] Rayl EA, Moroson BA, Beardsley GP (Mar 1996). „The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping”. J Biol Chem 271 (4): 2225–33. DOI:10.1074/jbc.271.4.2225. PMID 8567683.

[pmid9378707-2] Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). „Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase”. J Biochem 122 (2): 309–13. PMID 9378707.

[entrez-3] „Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase”.

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