Izvorni kod stranice Osemozotan

{{Drugbox
| verifiedrevid = 449585706
| IUPAC_name = 5-(3-[((2S)-1,4-benzodioksan-2-ilmetil)amino]propoksi)-1,3-benzodioksol
| image = Osemozotan.svg

<!--Clinical data-->
| tradename =  
| pregnancy_category =  
| legal_status = Nije kontrolisana supstanca
| routes_of_administration =

<!--Pharmacokinetic data-->
| bioavailability =  
| metabolism =  
| elimination_half-life =  
| excretion =

<!--Identifiers-->
| CAS_number = 137275-80-0
| ATC_prefix = none
| ATC_suffix =  
| PubChem = 198746
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID =  
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = M65825806Q

<!--Chemical data-->
| C=20 | H=23 | N=1 | O=4 
| molecular_weight = 341,400 g/mol
| smiles = c4cc1OCOc1cc4OCCCNCC3CCc2ccccc2O3
|  StdInChI = 1S/C20H23NO4/c1-2-5-18-15(4-1)6-7-17(25-18)13-21-10-3-11-22-16-8-9-19-20(12-16)24-14-23-19/h1-2,4-5,8-9,12,17,21H,3,6-7,10-11,13-14H2
| StdInChIKey_Ref   = {{stdinchicite|correct|chemspider}}
| StdInChI_comment  = 
|  StdInChIKey = FWJJRRVBVVQIBS-UHFFFAOYSA-N
| StdStdInChI_Ref   = {{stdinchicite|correct|chemspider}}
| density           = 
| melting_point     = 
| melting_high      = 
| melting_notes     = 
| boiling_point     = 
| boiling_notes     = 
| solubility        = 
| specific_rotation = 
| sec_combustion    =
}}

'''Osemozotan''' (''MKC-242'') je [[selektivnost vezivanja|selektivni]] [[agonist (farmakologija)|agonist]] [[5-HT1A receptor|5-HT<sub>1A</sub> receptora]] sa [[funkcionalna selektivnost|funkcionalnom selektivnošću]]. On deluje kao [[agonist (farmakologija)|pun agonist]] na presinaptičkim i kao [[parcijalni agonist]] na postsinaptičkim 5-HT<sub>1A</sub> receptorima.<ref>{{Cite journal
| pmid = 8786639
| year = 1995
| last1 = Matsuda | first1 = T.
| last2 = Yoshikawa | first2 = T.
| last3 = Suzuki | first3 = M.
| last4 = Asano | first4 = S.
| last5 = Somboonthum | first5 = P.
| last6 = Takuma | first6 = K.
| last7 = Nakano | first7 = Y.
| last8 = Morita | first8 = T.
| last9 = Nakasu | first9 = Y.
| title = Novel benzodioxan derivative, 5-(3-((2S)-1,4-benzodioxan-2- ylmethyl)aminopropoxy)-1,3-benzodioxole HCl (MKC-242), with a highly potent and selective agonist activity at rat central serotonin1A receptors
| volume = 69
| issue = 4
| pages = 357–366
| journal = Japanese journal of pharmacology
| doi = 10.1254/jjp.69.357
}}</ref> On pokazuje [[antidepresiv]]ne i [[anksiolitik|anksiolitske]] efekte u životinjskim studijama.<ref>{{Cite journal
| pmid = 8768745
| year = 1996
| last1 = Abe | first1 = M.
| last2 = Tabata | first2 = R.
| last3 = Saito | first3 = K.
| last4 = Matsuda | first4 = T.
| last5 = Baba | first5 = A.
| last6 = Egawa | first6 = M.
| title = Novel benzodioxan derivative, 5-3-((2S)-1,4-benzodioxan-2-ylmethyl) aminopropoxy-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models
| volume = 278
| issue = 2
| pages = 898–905
| journal = The Journal of Pharmacology and Experimental Therapeutics
}}</ref><ref>{{Cite journal
| doi = 10.1016/S0014-2999(02)02786-3
| pmid = 12498918
| year = 2003
| last1 = Sakaue | first1 = M.
| last2 = Ago | first2 = Y.
| last3 = Sowa | first3 = C.
| last4 = Koyama | first4 = Y.
| last5 = Baba | first5 = A.
| last6 = Matsuda | first6 = T.
| title = The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze
| volume = 458
| issue = 1–2
| pages = 141–144
| journal = European Journal of Pharmacology
}}</ref> Osemozotan se koristi za istraživanje uloge 5-HT<sub>1A</sub> receptora u modulaciji otpuštanja [[dopamin]]a i [[serotonin]]a u mozgu,<ref>{{Cite journal
| doi = 10.1038/sj.bjp.0703139
| pmid = 10696105
| year = 2000
| last1 = Sakaue | first1 = M.
| last2 = Somboonthum | first2 = P.
| last3 = Nishihara | first3 = B.
| last4 = Koyama | first4 = Y.
| last5 = Hashimoto | first5 = H.
| last6 = Baba | first6 = A.
| last7 = Matsuda | first7 = T.
| title = Postsynaptic 5-hydroxytryptamine1A receptor activation increases in vivo dopamine release in rat prefrontal cortex
| url = https://archive.org/details/sim_british-journal-of-pharmacology_2000-03_129_5/page/1028
| volume = 129
| issue = 5
| pages = 1028–1034
| pmc = 1571922
| journal = British Journal of Pharmacology 
}}</ref><ref>{{Cite journal
| pmid = 14614948
| year = 2003
| last1 = Ago | first1 = Y.
| last2 = Koyama | first2 = Y.
| last3 = Baba | first3 = A.
| last4 = Matsuda | first4 = T.
| title = Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex
| url = https://archive.org/details/sim_neuropharmacology_2003-12_45_8/page/1050
| volume = 45
| issue = 8
| pages = 1050–1056
| journal = Neuropharmacology
| doi = 10.1016/S0028-3908(03)00304-6
}}</ref> i njihovog učešća u adikciji na zloupotrebljene stimulante kao što su kokain i metamfetamin.<ref>{{Cite journal
| doi = 10.1016/j.neuropharm.2006.06.001
| pmid = 16863654
| year = 2006
| last1 = Ago | first1 = Y.
| last2 = Nakamura | first2 = S.
| last3 = Uda | first3 = M.
| last4 = Kajii | first4 = Y.
| last5 = Abe | first5 = M.
| last6 = Baba | first6 = A.
| last7 = Matsuda | first7 = T.
| title = Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice
| volume = 51
| issue = 4
| pages = 914–922
| journal = Neuropharmacology 
}}</ref><ref>{{Cite journal
| doi = 10.1016/j.pbb.2006.07.036
| pmid = 16962650
| year = 2006
| last1 = Ago | first1 = Y.
| last2 = Nakamura | first2 = S.
| last3 = Hayashi | first3 = A.
| last4 = Itoh | first4 = S.
| last5 = Baba | first5 = A.
| last6 = Matsuda | first6 = T.
| title = Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice
| url = https://archive.org/details/sim_pharmacology-biochemistry-and-behavior_2006-09_85_1/page/198
| volume = 85
| issue = 1
| pages = 198–205
| journal = Pharmacology, Biochemistry, and Behavior 
}}</ref><ref>{{Cite journal
| doi = 10.1254/jphs.FM0070121
| pmid = 18198473
| year = 2008
| last1 = Ago | first1 = Y.
| last2 = Nakamura | first2 = S.
| last3 = Baba | first3 = A.
| last4 = Matsuda | first4 = T.
| title = Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice
| volume = 106
| issue = 1
| pages = 15–21
| journal = Journal of pharmacological sciences
}}</ref><ref>{{Cite journal
| doi = 10.1254/jphs.08297FP
| pmid = 19270432
| year = 2009
| last1 = Tsuchida | first1 = R.
| last2 = Kubo | first2 = M.
| last3 = Kuroda | first3 = M.
| last4 = Shibasaki | first4 = Y.
| last5 = Shintani | first5 = N.
| last6 = Abe | first6 = M.
| last7 = Köves | first7 = K.
| last8 = Hashimoto | first8 = H.
| last9 = Baba | first9 = A.
| title = An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice
| volume = 109
| issue = 3
| pages = 396–402
| journal = Journal of pharmacological sciences
}}</ref><ref>{{Cite journal
| pmid = 19336914
| year = 2009
| last1 = Tsuchida | first1 = R.
| last2 = Kubo | first2 = M.
| last3 = Shintani | first3 = N.
| last4 = Abe | first4 = M.
| last5 = Köves | first5 = K.
| last6 = Uetsuki | first6 = K.
| last7 = Kuroda | first7 = M.
| last8 = Hashimoto | first8 = H.
| last9 = Baba | first9 = A.
| title = Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons
| volume = 32
| issue = 4
| pages = 728–731
| journal = Biological & Pharmaceutical Bulletin
| doi = 10.1248/bpb.32.728
}}</ref>

== Reference ==
{{Reflist|2}}

== Povezano ==
* [[Piklozotan]]
* [[Robalzotan]]
* [[Sarizotan]]
{{-}}
{{Serotonergici}}

[[Kategorija:Benzodioksoli]]
[[Kategorija:Fenolni etri]]
[[Kategorija:Hromani]]