Izvorni kod stranice Mačiji sarkomni onkogen

{{PBB|geneid=2242}}
'''Proto-onkogen tirosinske proteinske kinaze Fes/Fps''' je [[enzim]] koji je kod ljudi kodiran ''FES'' [[gen]]om.<ref name="pmid1870997">{{cite journal | author = Bowden DW, Akots G, Rothschild CB | title = An insertion deletion polymorphism associated with C-FES | journal = Nucleic Acids Res | volume = 19 | issue = 15 | pages = 4311 |date=September 1991 | pmid = 1870997 | pmc = 328602 | doi =10.1093/nar/19.15.4311  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FES feline sarcoma oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242| accessdate = }}</ref>

Ovaj gen kodira ljudski analog sarkomnog retrovirusnog proteina sa transformišućim sposobnostima. Ovaj genski produkt deluje kao [[tirozinska proteinska kinaza]]. Njegovo dejstvo je neophodno za održavanje [[Transformacija (genetika)|ćelijske transformacije]]. Njegova hromosomska lokacije je povezana sa specifičnim translokacionim događajem identifikovanim kod pacijenata sa akutnom promijelocitnom leukemijom. On takođe učestvuje u normalnoj [[Hematopoeza|hematopoezi]]. Poznat je i sktaćeni transkript, mada korespondirajući protein nije identifikovan.<ref name="entrez" />

==Interakcije==
Mačiji sarkomni onkogen formira [[Protein-protein interakcija|interakcije]] sa [[BCAR1]]<ref name=pmid8999909>{{cite journal |last=Jücker |first=M |authorlink= |author2=McKenna K |author3=da Silva A J |author4=Rudd C E |author5=Feldman R A  |date=January 1997  |title=The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling |journal=J. Biol. Chem. |volume=272 |issue=4 |pages=2104–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8999909 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.4.2104 }}</ref> i [[BCR gen]]om.<ref name=pmid10706130>{{cite journal |last=Lionberger |first=J M |authorlink= |author2=Smithgall T E |date=February 2000  |title=The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl |journal=Cancer Res. |volume=60 |issue=4 |pages=1097–103 |publisher= |location = UNITED STATES| issn = 0008-5472| pmid = 10706130 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid7529874>{{cite journal |last=Maru |first=Y |authorlink= |author2=Peters K L |author3=Afar D E |author4=Shibuya M |author5=Witte O N |author6=Smithgall T E  |date=February 1995  |title=Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS |journal=Mol. Cell. Biol. |volume=15 |issue=2 |pages=835–42 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 7529874 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1995-02_15_2/page/835| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=231961 }}</ref>

== Reference ==
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== Literatura ==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Smithgall TE, Rogers JA, Peters KL, et al. |title=The c-Fes family of protein-tyrosine kinases |journal=Critical reviews in oncogenesis |volume=9 |issue= 1 |pages= 43–62 |year= 1998 |pmid= 9754447 |doi=  10.1615/critrevoncog.v9.i1.40}}
*{{cite journal  | author=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063–70 |year= 2000 |pmid= 10856136 |doi=10.1067/mai.2000.107604  }}
*{{cite journal  | author=Greer P |title=Closing in on the biological functions of Fps/Fes and Fer |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 4 |pages= 278–89 |year= 2002 |pmid= 11994747 |doi= 10.1038/nrm783 }}
}}
{{refend}}

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[[Kategorija:Tirozinske kinaze]]