Izvorni kod stranice 5-HT1E receptor

{{DISPLAYTITLE:5-HT<sub>1E</sub> receptor}}
{{PBB|geneid=3354}}
'''5-HT1E receptor''', (''5-hidroksitriptaminski (serotoninski) 1E receptor'', 5-HT<sub>1E</sub>) je visoko izraženi humani [[G protein spregnuti receptori|G-protein spregnuti receptor]]<ref name="pmid2664084">{{cite journal | doi = 10.1111/j.1471-4159.1989.tb07357.x | author = Leonhardt S., Herrick-Davis K. and Titeler M. (1989) Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. Journal of neurochemistry 53, 465-471.| pmid = 2664084 | year = 1989 | title = Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein. | volume = 53 | issue = 2 | pages = 465–71 | journal = Journal of neurochemistry }}</ref> koji pripada familiji [[5-HT1 receptor]]a ([[Gi protein|G<sub>i</sub>]]-spregnutih serotoninskih receptora).<ref name="pmid1608964">{{cite journal | doi = 10.1073/pnas.89.12.5517 | author = McAllister G., Charlesworth A., Snodin C., Beer M. S., Noble A. J., Middlemiss D. N., Iversen L. L. and Whiting P. (1992) Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proceedings of the National Academy of Sciences of the United States of America 89, 5517-5521. | pmid = 1608964 | year = 1992 | title = Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. | volume = 89 | issue = 12 | pages = 5517–21 | pmc = 49323 | journal = Proceedings of the National Academy of Sciences of the United States of America}}</ref><ref name="pmid8001977">{{cite journal | author = Levy F. O., Gudermann T., Birnbaumer M., Kaumann A. J. and Birnbaumer L. (1992) Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. FEBS Lett 296, 201-206. | pmid = 8001977 | year = 1994 | title = Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15. | volume = 22 | issue = 3 | pages = 637–40 | doi = 10.1006/geno.1994.1439 | journal = Genomics }}</ref> Humani [[gen]] se označava sa {{Gene|HTR1E}}.<ref name="entrez">{{cite web | title = Entrez Gene: HTR1E 5-hydroxytryptamine (serotonin) receptor 1E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3354| accessdate = }}</ref>

== Funkcija ==
Funkcija 5-HT<sub>1E</sub> receptora nije poznata usled nedostatka selektivnih farmakoloških oruđa, specifičnih [[antitelo|antitela]], i podobnih životinjskih modela.<ref name="pmid19200348">{{cite journal | author = Klein, M. T., and M. Teitler. "Guinea Pig Hippocampal 5-Htie Receptors: A Tool for Selective Drug Development." J Neurochem 109, no. 1 (2009): 268-74. | pmid = 19200348 | year = 2009 | title = Guinea pig hippocampal 5-HT(1E) receptors: a tool for selective drug development. | volume = 109 | issue = 1 | pages = 268–74 | doi = 10.1111/j.1471-4159.2009.05958.x | pmc = 2827198 | journal = Journal of neurochemistry }}</ref> Gen 5-HT<sub>1E</sub> receptora nema polimorfizama među ljudima (mali je broj mutacija), što je indikacija visokog nivoa evolucione [[Genetička varijabilnost|konzervacije]] njegove genetičke sekvence, iz čega sledi da 5-HT<sub>1E</sub> receptor ima važnu fiziološku ulogu kod ljudi.<ref name="pmid7609628">{{cite journal | doi = 10.1016/0169-328X(95)00003-B | author = Shimron-Abarbanell D., Nothen M. M., Erdmann J. and Propping P. (1995) Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation. Brain Res Mol Brain Res 29, 387-390. | pmid = 7609628 | year = 1995 | title = Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation. | volume = 29 | issue = 2 | pages = 387–90 | journal = Brain research. Molecular brain research }}</ref> Pretpostavlja se da 5-HT<sub>1E</sub> receptor učestvuje u regulaciji [[memorija|memorije]] kod ljudi, zbog zbog visoke zastupljenosti ovog receptora u frontalnom korteksu, hipokampusu, i bulbus olfactorius, što su integralni moždani regioni za regulaciju memorije.<ref name="pmid14744596">{{cite journal | doi = 10.1016/j.ejphar.2003.11.019 | author = Bai F., Yin T., Johnstone E. M., Su C., Varga G., Little S. P. and Nelson D. L. (2004) Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. European journal of pharmacology 484, 127-139. | pmid = 14744596 | year = 2004 | title = Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. | volume = 484 | issue = 2-3 | pages = 127–39 | journal = European journal of pharmacology }}</ref>

Ovaj receptor je jedinstven među serotoninskim receptorima po tome što nije izražen kod [[Glodari|glodarskih]] vrsta. Tim vrstama nedostaje gen koji kodira 5-HT<sub>1E</sub> receptor. Međutim [[genom]]i svinje, rezus majmuna, i nekoliko lagomorfa (što obuhvata [[morsko prase]] i [[zec]]a) sadrže homologne 5-HT<sub>1E</sub> gene.<ref name="pmid14744596"/> Morsko prase je najverovatniji kandidat za buduća ispitivanja funkcije 5-HT<sub>1E</sub> receptor ''in vivo''. Izražavanje 5-HT<sub>1E</sub> receptora u mozgu morskog praseta je farmakološki potvrđeno. Obrasci izražavanja 5-HT<sub>1E</sub> receptora u mozgu ljudi i morskog praseta su slični.<ref name="pmid19200348"/>

== Selektivni ligandi ==
Visoko selektivni ligandi 5-HT<sub>1E</sub> još uvek nisu dostupni. [<sup>3</sup>H]5-HT je jedini dostupni radioligand visokog [[Konstanta disocijacije|afinita]] za 5-HT<sub>1E</sub> receptor (5 nM).

=== Agonisti ===
* [[BRL-54443]] (5-Hidroksi-3-(1-metilpiperidin-4-il)-1H-indol) - mešoviti 5-HT<sub>1E/1F</sub> agonist

=== Antagonisti ===
Antagonisti nisu poznati.

== Povezano ==
* [[5-HT1 receptor|5-HT<sub>1</sub> receptor]]
* [[5-HT receptor]]

== Reference ==
{{reflist|2}}

== Literatura ==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Zgombick JM, Schechter LE, Macchi M, ''et al.'' |title=Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor. |journal=Mol. Pharmacol. |volume=42 |issue= 2 |pages= 180–5 |year= 1992 |pmid= 1513320 |doi=  }}
*{{cite journal  | author=McAllister G, Charlesworth A, Snodin C, ''et al.'' |title=Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5517–21 |year= 1992 |pmid= 1608964 |doi=10.1073/pnas.89.12.5517  | pmc=49323  }}
*{{cite journal  | author=Levy FO, Gudermann T, Birnbaumer M, ''et al.'' |title=Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. |journal=FEBS Lett. |volume=296 |issue= 2 |pages= 201–6 |year= 1992 |pmid= 1733778 |doi=10.1016/0014-5793(92)80379-U  }}
*{{cite journal  | author=Levy FO, Holtgreve-Grez H, Taskén K, ''et al.'' |title=Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15. |journal=Genomics |volume=22 |issue= 3 |pages= 637–40 |year= 1995 |pmid= 8001977 |doi= 10.1006/geno.1994.1439 }}
*{{cite journal  | author=Pierce PA, Xie GX, Meuser T, Peroutka SJ |title=5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study. |journal=Neuroscience |volume=81 |issue= 3 |pages= 813–9 |year= 1997 |pmid= 9316030 |doi=10.1016/S0306-4522(97)00235-2  }}
}}
{{refend}}

== Spoljašnje veze ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2316 | title = 5-HT<sub>1e</sub> | accessdate =  | author =  | authorlink =  | coauthors =  | date =  | format =  | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages =  | language =  | archiveurl = https://web.archive.org/web/20160304215722/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2316 | archivedate = 2016-03-04 | quote =  | dead-url = yes }}
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{{G protein spregnuti receptori}}
{{Serotonergici}}

[[Kategorija:G protein spregnuti receptori]]