Vitamin D 25-hidroksilaza
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| Vitamin D 25-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.159 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Vitamin D 25-hidroksilaza (EC 1.14.13.159, vitamin D2 25-hidroksilaza, vitamin D3 25-hidroksilaza, CYP2R1) je enzim sa sistematskim imenom kalciol,NADPH:kiseonik oksidoreduktaza (25-hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj mikrozomalni enzim je izolovan iz jetre čoveka i sisara. On bioaktivira vitamin D3.
Reference[uredi | uredi kod]
- ↑ Cheng, J.B., Motola, D.L., Mangelsdorf, D.J. and Russell, D.W. (2003). „De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase”. J. Biol. Chem. 278: 38084-38093. PMID 12867411.
- ↑ Shinkyo, R., Sakaki, T., Kamakura, M., Ohta, M. and Inouye, K. (2004). „Metabolism of vitamin D by human microsomal CYP2R1”. Biochem. Biophys. Res. Commun. 324: 451-457. PMID 15465040.
- ↑ Strushkevich, N., Usanov, S.A., Plotnikov, A.N., Jones, G. and Park, H.W. (2008). „Structural analysis of CYP2R1 in complex with vitamin D3”. J. Mol. Biol. 380: 95-106. PMID 18511070.
- ↑ Zhu, J. and Deluca, H.F. (2012). „Vitamin D 25-hydroxylase - Four decades of searching, are we there yet ?”. Arch. Biochem. Biophys.: -. PMID 22310641.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.