UDP-2,3-diacilglukozaminska difosfataza
Prijeđi na navigaciju
Prijeđi na pretragu
| UDP-2,3-diacilglukozaminska difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.54 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
UDP-2,3-diacilglukozaminska difosfataza (EC 3.6.1.54, UDP-2,3-diacilglukozamin hidrolaza, UDP-2,3-diacilglukozamin pirofosfataza, ybbF (gen), lpxH (gen)) je enzim sa sistematskim imenom UDP-2,3-bis((3R)-3-hidroksimiristoil)-alfa-D-glukozamin 2,3-bis((3R)-3-hidroksimiristoil)-beta-D-glukozaminil 1-fosfat fosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-2,3-bis[(3R)-3-hidroksimiristoil]-alfa-D-glukozamin + H2O 2,3-bis[(3R)-3-hidroksimiristoil]-beta-D-glukozaminil 1-fosfat + UMP
Ovaj enzim katalizuje jedan od koraka biosinteze lipida A.
Reference[uredi | uredi kod]
- ↑ Babinski, K.J., Ribeiro, A.A. and Raetz, C.R. (2002). „The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis”. J. Biol. Chem. 277: 25937-25946. PMID 12000770.
- ↑ Babinski, K.J., Kanjilal, S.J. and Raetz, C.R. (2002). „Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene”. J. Biol. Chem. 277: 25947-25956. PMID 12000771.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.