Trans,policis-dekaprenil difosfat sintaza
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| Trans,policis-dekaprenil difosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.86 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trans,policis-dekaprenil difosfat sintaza (EC 2.5.1.86, Rv2361c, (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-dekaprenil difosfatna sintaza) je enzim sa sistematskim imenom (2Z,6E)-farnezil-difosfat:izopentenil-difosfat farnezilcistransferaza (dodaje 7 izopentenilnih jedinica).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2Z,6E)-farnezil difosfat + 7 izopentenil difosfat 7 difosfat + trans,oktacis-dekaprenil difosfat
Ovaj enzim učestvuje u biosintezi dekaprenil fosfata.
Reference[uredi | uredi kod]
- ↑ Kaur, D., Brennan, P.J. and Crick, D.C. (2004). „Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis”. J. Bacteriol. 186: 7564-7570. PMID 15516568.
- ↑ Wang, W., Dong, C., McNeil, M., Kaur, D., Mahapatra, S., Crick, D.C. and Naismith, J.H. (2008). „The structural basis of chain length control in Rv1086”. J. Mol. Biol. 381: 129-140. PMID 18597781.
- ↑ Crick, D.C., Schulbach, M.C., Zink, E.E., Macchia, M., Barontini, S., Besra, G.S. and Brennan, P.J. (2000). „Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis”. J. Bacteriol. 182: 5771-5778. PMID 11004176.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.