Tirozin-tRNK ligaza

Izvor: Wikipedia
Tirozin-tRNK ligaza
Identifikatori
EC broj 6.1.1.1
CAS broj 9023-45-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Tirozin-tRNK ligaza (EC 6.1.1.1) je enzim sa sistematskim imenom L-tirozin:tRNKTir ligaza (formira AMP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-tirozin + tRNKTyr \rightleftharpoons AMP + difosfat + L-tirozil-tRNKTyr

Reference[uredi - уреди]

  1. Allen, E.H., Glassman, E. and Schweet, R.S. (1960). "Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes". J. Biol. Chem. 235: 1061-1067. PMID 13792726. 
  2. Cowles, J.R. and Key, J.L. (1972). "Demonstration of two tyrosyl-tRNA synthetases of pea roots". Biochim. Biophys. Acta 281: 33-44. PMID 4563531. 
  3. Holley, R.W., Brunngraber, E.F., Saad, F. and Williams, H.H. (1961). "Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of potassium ions on the activity of the tyrosine enzyme". J. Biol. Chem. 236: 197-199. PMID 13715350. 
  4. Schweet, R.S. and Allen, E.H. (1958). "Purification and properties of tyrosine-activating enzyme of hog pancreas". J. Biol. Chem. 233: 1104-1108. PMID 13598741. 
  5. Brick, P., Bhat, T.N. and Blow, D.M. (1989). "Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate". J. Mol. Biol. 208: 83-98. PMID 2504923. 

Literatura[uredi - уреди]

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