Skutelarin (enzim)
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| Skutelarin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.60 | ||||||||
| CAS broj | 93389-45-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Skutelarin (EC 3.4.21.60, oksiuranus scutellatus protrombin-aktivirajuća proteinaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selektivno razlaganje veza Arg-Thr i Arg-Ile u protrombinu čime se formira trombin i dva neaktivna fragmenta
Ovaj enzim je izolovan iz venima zmije Tajpan (Oksiuranus scutellatus).
Reference[uredi | uredi kod]
- ↑ Walker, F.J., Owen, W.G. and Esmon, C.T. (1980). „Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom)”. Biochemistry 19: 1020-1023. PMID 6986908.
- ↑ Speijer, H., Govers-Reimslag, J.W., Zwaal, R.F. and Rosing, J. (1986). „Prothrombin activation by an activator from the venom of Oxyuranus scutellatus (taipan snake)”. J. Biol. Chem. 261: 13258-13267. PMID 3531198.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.