Propanoil-KoA C-aciltransferaza
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| Propanoil-KoA C-aciltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.176 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Propanoil-KoA C-aciltransferaza (EC 2.3.1.176, peroksizomalna tiolaza 2, sterolni nosilac protein-chi, SCPchi, PTE-2) je enzim sa sistematskim imenom 3alfa,7alfa,12alfa-trihidroksi-5beta-holanoil-KoA:propanoil-KoA C-aciltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3alfa,7alfa,12alfa-trihidroksi-5beta-holanoil-KoA + propanoil-KoA KoA + 3alfa,7alfa,12alfa-trihidroksi-24-okso-5beta-holestanoil-KoA
Ovaj takođe deluje na dihidroksi-5beta-holestanoil-KoA i druge acil-KoA derivate razgranatog lanca.
Reference[uredi | uredi kod]
- ↑ Pedersen, J.I. and Gustafsson, J. (1980). „Conversion of 3α,7α,12α-trihydroxy-5β-cholestanoic acid into cholic acid by rat liver peroxisomes”. FEBS Lett. 121: 345-348. PMID 7461136.
- ↑ Kase, F., Björkhem, I. and Pedersen, J.I. (1983). „Formation of cholic acid from 3α,7α,12α-trihydroxy-5β-cholestanoic acid by rat liver peroxisomes”. J. Lipid Res. 24: 1560-1567. PMID 6668450.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
- ↑ Falany, C.N., Johnson, M.R., Barnes, S. and Diasio, R.B. (1994). „Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase”. J. Biol. Chem. 269: 19375-19379. PMID 8034703.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.