Prolin 3-hidroksilaza
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| Prolin 3-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.28 | ||||||||
| CAS broj | 162995-24-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prolin 3-hidroksilaza (EC 1.14.11.28, P-3-H) je enzim sa sistematskim imenom L-prolin,2-oksoglutarat:kiseonik oksidoreduktaza (3-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za rad ovog enzima je neophodan Fe2+ jon.
Reference[uredi | uredi kod]
- ↑ Mori, H., Shibasaki, T., Uozaki, Y., Ochiai, K. and Ozaki, A. (1996). „Detection of novel proline 3-hydroxylase activities in Streptomyces and Bacillus spp. by regio- and stereospecific hydroxylation of L-proline”. Appl. Environ. Microbiol. 62: 1903-1907. PMID 16535329.
- ↑ Mori, H., Shibasaki, T., Yano, K. and Ozaki, A. (1997). „Purification and cloning of a proline 3-hydroxylase, a novel enzyme which hydroxylates free L-proline to cis-3-hydroxy-L-proline”. J. Bacteriol. 179: 5677-5683. PMID 9294421.
- ↑ Clifton, I.J., Hsueh, L.C., Baldwin, J.E., Harlos, K. and Schofield, C.J. (2001). „Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases”. Eur. J. Biochem. 268: 6625-6636. PMID 11737217.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.