Pikornain 3C

Izvor: Wikipedia
Pikornain 3C
Identifikatori
EC broj 3.4.22.28
CAS broj 97162-88-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Pikornain 3C (EC 3.4.22.28, pikornavirusna endopeptidaza 3C, poliovirusna proteaza 3C, rinovirusna proteaza 3C, proteaza 3C bolesti slinavka i šap, poliovirusna proteinaza 3C, rinovirusna proteinaza 3C, koksakievirusna 3C proteinaza, proteinaza 3C virusa bolesti slinavka i šap, 3C proteaza, 3C proteinaza, cisteinska proteinaza 3C, hepatitis A virusna 3C proteinaza, proteaza 3C, proteinaza 3C srodana sa nepovirusom prstenastih mrlja paradajza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno razlaganje Gln-Gly veze u poliovirusnom poliproteinu. U drugim pikornavirusnim reakcijama Glu može da bude supstituisan sa Gln, i Ser ili Thr za Gly

Ovaj enzim izražavaju entero-, rino-, afto- i kardiovirusi.

Reference[uredi - уреди]

  1. Ivanoff, L.A., Towatari, T., Ray, J., Korant, B.D. and Petteway, S.R. (1986). "Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli". Proc. Natl Acad. Sci. USA 83: 5392–5396. PMID 3016701. 
  2. Bazan, J.F. and Fletterick, R.J. (1988). "Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications". Proc. Natl Acad. Sci. USA 85: 7872–7876. PMID 3186696. 
  3. Kräusslich, H.-G. and Wimmer, E. (1988). "Viral proteinases". Annu. Rev. Biochem. 57: 701–754. PMID 3052288. 
  4. Nicklin, M.J.H., Harris, K.S., Pallai, P.V. and Wimmer, E. (1988). "Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro". J. Virol. 62: 4586–4593. PMID 2846872. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]