Pentalenolakton F sintaza
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| Pentalenolakton F sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.36 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pentalenolakton F sintaza (EC 1.14.11.36, PEND (gen), PNTD (gen), PTLD (gen)) je enzim sa sistematskim imenom pentalenolakton-D,2-oksoglutarat:kiseonik oksidoreduktaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- pentalenolakton D + 2 2-oksoglutarat + 2 O2 pentalenolakton F + 2 sukcinat + 2 CO2 +H2O (sveukupna reakcija)
- (1a) pentalenolaktan D + 2-oksoglutarat + O2 pentalenolaktan E + sukcinat + CO2 +H2O
- (1b) pentalenolaktan E + 2-oksoglutarat + O2 pentalenolaktan F + sukcinat + CO2
Za dejstvo ovog enzima su neophodni Fe(II) i askorbat. On je izolovan iz bakterija Streptomyces exfoliatus, Streptomyces arenae i Streptomyces avermitilis. Ovaj enzim učestvuje u biosintezi pentalenolaktona.
Reference[uredi | uredi kod]
- ↑ Seo, M.J., Zhu, D., Endo, S., Ikeda, H. and Cane, D.E. (2011). „Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone”. Biochemistry 50: 1739-1754. PMID 21250661.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.