Papalizin 1

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Papalizin 1
Identifikatori
EC broj 3.4.24.79
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Papalizin 1 (EC 3.4.24.79, proteaza insulinu-sličnog faktora vezujućeg proteina-4) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje Met135-Lys veze u insulinu-sličnom faktor rasta vezujućem proteinu (IGFBP4), i Ser143-Lys veze u IGFBP5

Ovaj enzip pripada peptidaznoj familiji M43.

Reference[uredi - уреди]

  1. Lawrence, J.B., Oxvig, C., Overgaard, M.T., Sottrup-Jensen, L., Gleich, G.J. (1999). ", Hays L.G., Yates, J.R. 3rd, and Conover, C.A. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A". Proc. Natl. Acad. Sci. USA 96: 3149–3153. PMID 10077652. 
  2. Chen, B.K., Overgaard, M.T., Bale, L.K., Resch, Z.T., Christiansen, M., Oxvig, C. and Conover, C.A. (2002). "Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor". Endocrinology 143: 1199–1205. PMID 11897673. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]