Panteteinska hidrolaza
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| Panteteinska hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.92 | ||||||||
| CAS broj | 56093-18-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Panteteinska hidrolaza (EC 3.5.1.92, panteteinaza, vanin, vanin-1) je enzim sa sistematskim imenom (R)-pantetein amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-pantetein + H2O (R)-pantotenat + 2-aminoetantiol
Ovaj enzim hidrolizuje jednu od amidnih veza panteteina.
Reference[uredi | uredi kod]
- ↑ Duprè, S. and Cavallini, D. (1979). „Purification and properties of pantetheinase from horse kidney”. Methods Enzymol. 62: 262-267. PMID 440106.
- ↑ Duprè, S., Chiaraluce, R., Nardini, M., Cannella, C., Ricci, G. and Cavallini, D. (1984). „Continuous spectrophotometric assay of pantetheinase activity”. Anal. Biochem. 142: 175-181. PMID 6549111.
- ↑ Maras, B., Barra, D., Duprè, S. and Pitari, G. (1999). „Is pantetheinase the actual identity of mouse and human vanin-1 proteins?”. FEBS Lett. 461: 149-152. PMID 10567687.
- ↑ Aurrand-Lions, M., Galland, F., Bazin, H., Zakharyev, V.M., Imhof, B.A. and Naquet, P. (1996). „Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing”. Immunity 5: 391-405. PMID 8934567.
- ↑ Pitari, G., Malergue, F., Martin, F., Philippe, J.M., Massucci, M.T., Chabret, C., Maras, B., Duprè, S., Naquet, P. and Galland, F. (2000). „Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice”. FEBS Lett. 483: 149-154. PMID 11042271.
- ↑ Martin, F., Malergue, F., Pitari, G., Philippe, J.M., Philips, S., Chabret, C., Granjeaud, S., Mattei, M.G., Mungall, A.J., Naquet, P. and Galland, F. (2001). „Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes”. Immunogenetics 53: 296-306. PMID 11491533.
- ↑ Pace, H.C. and Brenner, C. (2001). „The nitrilase superfamily: classification, structure and function”. Genome Biol. 2: 0001.-001.9. PMID 11380987.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.