Pankreasna elastaza II
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| Pankreasna elastaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.71 | ||||||||
| CAS broj | 75603-19-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Pankreasna elastaza II (EC 3.4.21.71, pankreasna elastaza 2) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno razlaganje veza: Leu-, Met- i Phe-. Dolazi do hidrolize elastina
Ova peptidaza iz S1 familije (tripsinske familije) se formira aktivacijom proelastaze II iz sisarskog pankreasa posredstvom tripsina.
Reference[uredi | uredi kod]
- ↑ Fletcher, T.S., Shen, W.-F. and Largman, C. (1987). „Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA”. Biochemistry 26: 7256-7261. PMID 3427074.
- ↑ Shirasu, Y., Yoshida, H., Matsuki, S., Takemura, K., Ikeda, N., Shimada, Y., Ozawa, T., Mikayama, T., Iijima, H., Ishida, A., Sato, Y., Tamai, Y., Tanaka, J. and Ikenaga, H. (1987). „Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2”. J. Biochem. (Tokyo) 102: 1555-1563. PMID 2834346.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.