Ornitin ciklodeaminaza
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| Ornitin ciklodeaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.1.12 | ||||||||
| CAS broj | 9054-76-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ornitin ciklodeaminaza (EC 4.3.1.12, ornitinska ciklaza, ornitinska ciklaza (deaminacija), OCD) je enzim sa sistematskim imenom L-ornitin amonijak-lijaza (ciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-ornitin L-prolin + NH3
Ovaj enzim je član mi-kristalinske proteinske familije. Reakciju stimuliše prisustvo ADP ili ATP, a inhibira je O2.
Reference[uredi | uredi kod]
- ↑ Costilow, R.N. and Laycock, L. (1971). „Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions”. J. Biol. Chem. 246: 6655-6660. PMID 4399881.
- ↑ Muth, W.L. and Costilow, R.N. (1974). „Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme”. J. Biol. Chem. 249: 7457-7462. PMID 4373469.
- ↑ Espineda, C.E., Linford, A.S., Devine, D. and Brusslan, J.A. (1999). „The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana”. Proc. Natl. Acad. Sci. USA 96: 10507-10511. PMID 10468639.
- ↑ Goodman, J.L., Wang, S., Alam, S., Ruzicka, F.J., Frey, P.A. and Wedekind, J.E. (2004). „Ornithine cyclodeaminase: structure, mechanism of action, and implications for the μ-crystallin family”. Biochemistry 43: 13883-13891. PMID 15518536.
- ↑ Alam, S., Wang, S.C., Ruzicka, F.J., Frey, P.A. and Wedekind, J.E. (2004). „Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida”. Acta Crystallogr. D Biol. Crystallogr. 60: 941-944. PMID 15103146.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.