Nitroalkan oksidaza
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| Nitroalkan oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.3.1 | ||||||||
| CAS broj | 65802-82-6&title= 9029-36-1, 65802-82-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nitroalkan oksidaza (EC 1.7.3.1, nitroetanska oksidaza, NAO, nitroetan:kiseonik oksidoreduktaza) je enzim sa sistematskim imenom nitroalkan:kiseonik oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za rad ovog enzima je neophodan FAD. Nitroetan je fiziološki supstrat. On takođe deluje na nekoliko drugih nitroalkana, uključujući 1-nitropropan, 2-nitropropan, 1-nitrobutan, 1-nitropentan, 1-nitroheksan, nitrocikloheksan i neke nitroalkanole.
Reference[uredi | uredi kod]
- ↑ Little, H.N. (1951). „Oxidation of nitroethane by extracts from Neurospora”. J. Biol. Chem. 193: 347-358. PMID 14907722.
- ↑ Kido, T., Hashizume, K. and Soda, K. (1978). „Purification and properties of nitroalkane oxidase from Fusarium oxysporum”. J. Bacteriol. 133: 53-58. PMID 22538.
- ↑ Daubner, S.C., Gadda, G., Valley, M.P. and Fitzpatrick, P.F. (2002). „Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily”. Proc. Natl. Acad. Sci. USA 99: 2702-2707. PMID 11867731.
- ↑ Fitzpatrick, P.F., Orville, A.M., Nagpal, A. and Valley, M.P. (2005). „Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase”. Arch. Biochem. Biophys. 433: 157-165. PMID 15581574.
- ↑ Valley, M.P., Tichy, S.E. and Fitzpatrick, P.F. (2005). „Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase”. J. Am. Chem. Soc. 127: 2062-2066. PMID 15713081.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.