Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza
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| Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.21 | ||||||||
| CAS broj | 37277-76-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nikotinat-nukleotid—dimetilbenzimidazol fosforiboziltransferaza (EC 2.4.2.21, nikotinat mononukleotid-dimetilbenzimidazolna fosforiboziltransferaza, nikotinat ribonukleotid:benzimidazol (adenin) fosforiboziltransferaza, nikotinat-nukleotid:dimetilbenzimidazol fosfo-D-riboziltransferaza, CobT, nikotinat mononukleotid (NaMN):5,6-dimetilbenzimidazol fosforiboziltransferaza) je enzim sa sistematskim imenom nikotinat-nukleotid:5,6-dimetilbenzimidazol fosfo-D-riboziltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- beta-nikotinat D-ribonukleotid + 5,6-dimetilbenzimidazol nikotinat+ alfa-ribazole 5'-fosfat
Ovaj enzim takođe deluje na benzimidazol.
Reference[uredi | uredi kod]
- ↑ Friedmann, H.C. (1965). „Partial purification and properties of a single displacement trans-N-glycosidase”. J. Biol. Chem. 240: 413-418. PMID 14253445.
- ↑ Friedmann, H.C. and Fyfe, J.A. (1969). „Pseudovitamin B12 biosynthesis. Enzymatic formation of a new adenylic acid, 7-α-D-ribofuranosyladenine 5′-phosphate”. J. Biol. Chem. 244: 1667-1671. PMID 5780835.
- ↑ Fyfe, J.A. and Friedmann, H.C. (1969). „Vitamin B12 biosynthesis. Enzyme studies on the formation of the α-glycosidic nucleotide precursor”. J. Biol. Chem. 244: 1659-1666. PMID 4238408.
- ↑ Cameron, B., Blanche, F., Rouyez, M.C., Bisch, D., Famechon, A., Couder, M., Cauchois, L., Thibaut, D., Debussche, L. and Crouzet, J. (1991). „Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase”. J. Bacteriol. 173: 6066-6073. PMID 1917841.
- ↑ Cheong, C.G., Escalante-Semerena, J.C. and Rayment, I. (2001). „Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica”. J. Biol. Chem. 276: 37612-37620. PMID 11441022.
- ↑ Cheong, C.G., Escalante-Semerena, J.C. and Rayment, I. (2002). „Capture of a labile substrate by expulsion of water molecules from the active site of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enterica”. J. Biol. Chem. 277: 41120-41127. PMID 12101181.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.