N2-citril-N6-acetil-N6-hidroksilizinska sintaza
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| N2-citril-N6-acetil-N6-hidroksilizinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.38 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N2-citril-N6-acetil-N6-hidroksilizinska sintaza (EC 6.3.2.38, Nalfa-citril-Nepsilon-acetil-Nepsilon-hidroksilizin sintaza, iucA (gen)) je enzim sa sistematskim imenom citrat:N6-acetil-N6-hidroksi-L-lizin ligaza (formira ADP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 ATP + citrat + N6-acetil-N6-hidroksi-L-lizin + H2O 2 ADP + 2 fosfat + N2-citril-N6</supu>-acetil-N6-hidroksi-L-lizin
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference[uredi | uredi kod]
- ↑ Appanna, D.L., Grundy, B.J., Szczepan, E.W. and Viswanatha, T. (1984). „Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1”. Biochim. Biophys. Acta 801: 437-443.
- ↑ Gibson, F. and Magrath, D.I. (1969). „The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I”. Biochim. Biophys. Acta 192: 175-184. PMID 4313071.
- ↑ Maurer, P.J. and Miller, M. (1982). „Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N6-acetyl-N6-hydroxylysine”. J. Am. Chem. Soc. 104: 3096-3101.
- ↑ de Lorenzo, V., Bindereif, A., Paw, B.H. and Neilands, J.B. (1986). „Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12”. J. Bacteriol. 165: 570-578. PMID 2935523.
- ↑ Challis, G.L. (2005). „A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases”. ChemBioChem 6: 601-611. PMID 15719346.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.