N-karbamoil-L-aminokiselinska hidrolaza
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| N-karbamoil-L-aminokiselinska hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.87 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-karbamoil-L-aminokiselinska hidrolaza (EC 3.5.1.87, N-karbamil L-aminokiselinska amidohidrolaza, N-karbamoil-L-aminokiselinska amidohidrolaza, L-N-karbamoilaza, N-karbamoilaza) je enzim sa sistematskim imenom N-karbamoil-L-aminokiselina amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N-karbamoil-L-2-aminokiselina (2-ureido karboksilat) + H2O L-2-aminokiselina + NH3 + CO2
Ovaj enzim zajedno sa EC 3.5.1.77 (N-karbamoil-D-aminokiselinskom hidrolazom), EC 5.1.99.5 (hidantoinskom racemazom) i hidantoinazom, formira deo reakcione kaskade poznate kao hidantoinazni proces.
Reference[uredi | uredi kod]
- ↑ Ogawa, J., Miyake, H. and Shimizu, S. (1995). „Purification and characterization of N-carbamoyl-L-amino acid amidohydrolase with broad substrate specificity from Alcaligenes xylosoxidans”. Appl. Microbiol. Biotechnol. 43: 1039-1043. PMID 8590654.
- ↑ Martínez-Rodríguez, S., Clemente-Jiménez, J.M., Rodríguez-Vico, F. and Las Heras-Vázquez, F.J. (2005). „Molecular cloning and biochemical characterization of L-N-carbamoylase from Sinorhizobium meliloti CECT4114”. J. Mol. Microbiol. Biotechnol. 9: 16-25. PMID 16254442.
- ↑ Altenbuchner, J., Siemann-Herzberg, M. and Syldatk, C. (2001). „Hydantoinases and related enzymes as biocatalysts for the synthesis of unnatural chiral amino acids”. Curr. Opin. Biotechnol. 12: 559-563. PMID 11849938.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.