N-acilneuraminat-9-fosfat sintaza
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| N-acilneuraminat-9-fosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.57 | ||||||||
| CAS broj | 9031-58-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-acilneuraminat-9-fosfat sintaza (EC 2.5.1.57, N-acetilneuraminat 9-fosfat lijaza, N-acetilneuraminat 9-fosfat sijalinska kiselina 9-fosfatna sintaza, N-acetilneuraminat 9-fosfatna sintetaza, N-acilneuraminat-9-fosfat piruvat-lijaza (piruvatna fosforilacija), sijalinska kiselina 9-fosfatna sintetaza) je enzim sa sistematskim imenom fosfoenolpiruvat:N-acil-D-manozamin-6-fosfat 1-(2-karboksi-2-oksoetil)transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fosfoenolpiruvat + N-acil-D-manozamin 6-fosfat + H 2O N-acilneuraminat 9-fosfat + fosfat
Ovaj enzim deluje na N-glikoloil i N-acetil-derivate.
Reference[uredi | uredi kod]
- ↑ Roseman, S., Jourdian, G.W., Watson, D. and Rood, R. (1961). „Enzymatic synthesis of sialic acid 9-phosphates”. Proc. Natl. Acad. Sci. USA 47: 958-961. PMID 13743311.
- ↑ Watson, D.R., Jourdian, G.W. and Roseman, S. (1966). „The sialic acids. 8. Sialic acid 9-phosphate synthetase”. J. Biol. Chem. 241: 5627-5636. PMID 5928202.
- ↑ Nakata, D., Close, B.E., Colley, K.J., Matsuda, T. and Kitajima, K. (2000). „Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity”. Biochem. Biophys. Res. Commun. 273: 642-648. PMID 10873658.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.