Miricetin O-metiltransferaza
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| Miricetin O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.149 | ||||||||
| CAS broj | 188132-36-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Miricetin O-metiltransferaza (EC 2.1.1.149, Myricetin O-methyltransferase) je enzim sa sistematskim imenom S-adenozil-L-metionin:miricetin O-metiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 S-adenozil-L-metionin + miricetin 2 S-adenozil-L-homocistein + siringetin (sveukupna reakcija)
- (1a) S-adenozil-L-metionin + miricetin S-adenozil-L-homocistein + laricitrin
- (1b) S-adenozil-L-metionin + laricitrin S-adenozil-L-homocistein + siringetin
Enzim iz Catharanthus ruža (Madagascar periwinkle) je neobičan po tome što izvodi dve metilacije istog supstrata. On takođe katalizuje metilaciju dihidromiricetina.
Reference[uredi | uredi kod]
- ↑ Cacace, S., Schröder, G., Wehinger, E., Strack, D., Schmidt, J. and Schröder, J. (2003). „A flavonol O-methyltransferase from Catharanthus roseus performing two sequential methylations”. Phytochemistry 62: 127-137. PMID 12482447.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.