Miozin laki lanac kinaza

Izvor: Wikipedia
Miozin laki lanac kinaza
SkMLCK.png
Identifikatori
EC broj 2.7.11.18
CAS broj 51845-53-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Miozin laki lanac kinaza (EC 2.7.11.18, (miozin-laki-lanac) kinaza, ATP:miozin-laki-lanac O-fosfotransferaza, kinaza kalcium/kalmodulin-zavisnog miozinskog lakog lanaca, MLCK, MLCKaza, miozinska kinaza, kinaza miozinskog lakog lanca, proteinska kinaza miozinskog lakog lanca, kinaza miozinskog lakog-lanca (fosforilacija), kinaza glatko mišičnog miozina lakog-lanca, STK18) je enzim sa sistematskim imenom ATP:(miozin laki lanac) O-fosfotransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [miozin laki lanac] \rightleftharpoons ADP + [miozin laki lanac] fosfat

Za rad ovog enzima je neophodan jon Ca2+ i kalmodulin.

Reference[uredi - уреди]

  1. Adelstein, R.S. and Klee, C.B. (1981). "Purification and characterization of smooth muscle myosin light chain kinase". J. Biol. Chem. 256: 7501–7509. PMID 6894756. 
  2. Hathaway, D.R. and Adelstein, R.S. (1979). "Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity". Proc. Natl. Acad. Sci. USA 76: 1653–1657. PMID 156362. 
  3. Pires, E., Perry, S.V. and Thomas, M.A.W. (1974). "Myosin light-chain kinase, a new enzyme from striated muscle". FEBS Lett. 41: 292–296. PMID 4853304. 
  4. Nunnally, M.H., Rybicki, S.B. and Stull, J.T. (1985). "Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes". J. Biol. Chem. 260: 1020–1026. PMID 3881420. 
  5. Edelman, A.M., Takio, K., Blumenthal, D.K., Hansen, R.S., Walsh, K.A., Titani, K. and Krebs, E.G. (1985). "Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase". J. Biol. Chem. 260: 11275–11285. PMID 3897230. 
  6. Mal, T.K., Skrynnikov, N.R., Yap, K.L., Kay, L.E. and Ikura, M. (2002). "Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR". Biochemistry 41: 12899–12906. PMID 12390014. 
  7. Sobieszek, A. (1999). "Enzyme kinetic characterization of the smooth muscle myosin phosphorylating system: activation by calcium and calmodulin and possible inhibitory mechanisms of antagonists". Biochim. Biophys. Acta 1450: 77–91. PMID 10231558. 
  8. Sobieszek, A., Borkowski, J. and Babiychuk, V.S. (1997). "Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex". J. Biol. Chem. 272: 7034–7041. PMID 9054394. 
  9. Fujita, K., Ye, L.H., Sato, M., Okagaki, T., Nagamachi, Y. and Kohama, K. (1999). "Myosin light chain kinase from skeletal muscle regulates an ATP-dependent interaction between actin and myosin by binding to actin". Mol. Cell. Biochem. 190: 85–90. PMID 10098974. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]