Mikotiol sintaza
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| Mikotiol sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.189 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Mikotiol sintaza (EC 2.3.1.189, MshD) je enzim sa sistematskim imenom acetil-KoA:desacetilmikotiol O-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- desacetilmikotiol + acetil-KoA KoA + mikotiol
Ovaj enzim katalizuje zadnji korak u biosinteza mikotiola, glavnog tiola većine aktinomiceta, uključujući Mycobacterium.
Reference[uredi | uredi kod]
- ↑ Spies, H.S. and Steenkamp, D.J. (1994). „Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis”. Eur. J. Biochem. 224: 203-213. PMID 8076641.
- ↑ Koledin, T., Newton, G.L. and Fahey, R.C. (2002). „Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes”. Arch. Microbiol. 178: 331-337. PMID 12375100.
- ↑ Vetting, M.W., Roderick, S.L., Yu, M. and Blanchard, J.S. (2003). „Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases”. Protein Sci. 12: 1954-1959. PMID 12930994.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.