Medroksiprogesteron

Izvor: Wikipedia
Medroksiprogesteron
(IUPAC) ime
(1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hidroksi-2,8,15-trimetiltetraciklo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Klinički podaci
Robne marke Aragest, Aragest 5, Asconale, Clinofem
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 520-85-4
ATC kod G03AC06 , L02AB02
PubChem[1][2] 10631
DrugBank DB00603
ChemSpider[3] 10185
KEGG[4] C07119 YesY
ChEMBL[5] CHEMBL6715 YesY
Hemijski podaci
Formula C22H32O3 
Mol. masa 344.4877
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 214.5 °C (418 °F)
Farmakokinetički podaci
Poluvreme eliminacije 50 dana
Izlučivanje Nakon oralnog doziranja, MPA se ekstenzivno metaboliše u jetri hidroksilacijom
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status
Način primene Intramaskularno; Oralno;

Medroksiprogesteron ((6 alfa)-17-hidroksi-6-metilpregn-4-en-3,20-dion) je sintetički progestinski hormon koji se koristi u veterinarskoj praksi za regulaciju polnog ciklusa ženki.[6][7]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMID 21059682. 
  7. Nucleic Acids Res (2008). DrugBank: a knowledgebase for drugs, drug actions and drug targets 36 (Database issue). pp. D901–6. PMID 18048412. 

Spoljašnje veze[uredi - уреди]

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