Mandelonitrilna lijaza

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Mandelonitrilna lijaza
Mandelonitrile lyase.png
Identifikatori
EC broj 4.1.2.10
CAS broj 9024-43-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Mandelonitrilna lijaza (EC 4.1.2.10, (R)-oksinitrilaza, oksinitrilaza, D-oksinitrilaza, D-alfa-hidroksinitril lijaza, mandelonitril benzaldehid-lijaza, PaHNL, AtHNL, PhaMDL, (R)-HNL, (R)-PeHNL, (R)-hidroksinitril lijaza, R-selektivna hidroksinitrilna lijaza, R-selektivna HNL, (R)-(+)-mandelonitrilna lijaza) je enzim sa sistematskim imenom (R)-mandelonitril benzaldehid-lijaza (formira cijanid).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(R)-mandelonitril \rightleftharpoons cijanid + benzaldehid

Ova enzimska klasa obuhvata raznovrsne enzime iz različitih izvora.

Reference[uredi - уреди]

  1. Ueatrongchit, T., Kayo, A., Komeda, H., Asano, Y. and H-Kittikun, A. (2008). "Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat)". Biosci. Biotechnol. Biochem. 72: 1513-1522. PMID 18540101. 
  2. Lin, G., Han, S. and Li, Z. (1999). "Enzymic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous organic medium". Tetrahedron 55: 3531-3540. 
  3. de Gonzalo, G., Brieva, R. and Gotor, V. (2002). "(R)-Oxynitrilase-catalyzed transformation of ω-hydroxyalkanals". J. Mol. Catal. B 19-20: 223-230. 
  4. Ueatrongchit, T., Tamura, K., Ohmiya, T., H-Kittikun, A. and Asano, Y. (2010). "Hydroxynitrile lyase from Passiflora edulis. Purification, characteristics and application in asymmetric synthesis of (R)-mandelonitrile". Enzyme Microb. Technol. 46: 456-465. 
  5. Andexer, J., von Langermann, J., Mell, A., Bocola, M., Kragl, U., Eggert, T. and Pohl, M. (2007). "An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an α/β-hydrolase fold". Angew. Chem. Int. Ed. Engl. 46: 8679-8681. PMID 17907254. 
  6. Guterl, J.K., Andexer, J.N., Sehl, T., von Langermann, J., Frindi-Wosch, I., Rosenkranz, T., Fitter, J., Gruber, K., Kragl, U., Eggert, T. and Pohl, M. (2009). "Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with α/β-hydrolase fold". J. Biotechnol. 141: 166-173. PMID 19433222. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]