Malonil-KoA O-metiltransferaza
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| Malonil-KoA O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.197 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Malonil-KoA O-metiltransferaza (EC 2.1.1.197, BioC) je enzim sa sistematskim imenom S-adenozil-L-metionin:malonil-KoA O-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + malonil-KoA S-adenozil-L-homocistein + malonil-KoA metil estar
Ovaj enzim učestvuje u početnom delu biosinteze Gram-negativnih bakterija. On katalizuje transfer metil grupe na omega-karboksilnu grupu pri čemu se formira malonil-KoA metil estar. Taj estar prepoznaju enzimi sinteze masnih kiselina, koji produžavaju masne kiseline i formiraju pimelil-[acil-nosilac-protein] metil estar.
Reference[uredi | uredi kod]
- ↑ Del Campillo-Campbell, A., Kayajanian, G., Campbell, A. and Adhya, S. (1967). „Biotin-requiring mutants of Escherichia coli K-12”. J. Bacteriol. 94: 2065-2066. PMID 4864413.
- ↑ Rolfe, B. and Eisenberg, M.A. (1968). „Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12”. J. Bacteriol. 96: 515-524. PMID 4877129.
- ↑ Otsuka, A.J., Buoncristiani, M.R., Howard, P.K., Flamm, J., Johnson, C., Yamamoto, R., Uchida, K., Cook, C., Ruppert, J. and Matsuzaki, J. (1988). „The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon”. J. Biol. Chem. 263: 19577-19585. PMID 3058702.
- ↑ Cleary, P.P. and Campbell, A. (1972). „Deletion and complementation analysis of biotin gene cluster of Escherichia coli”. J. Bacteriol. 112: 830-839. PMID 4563978.
- ↑ Lin, S., Hanson, R.E. and Cronan, J.E. (2010). „Biotin synthesis begins by hijacking the fatty acid synthetic pathway”. Nat. Chem. Biol.: -. PMID 20693992.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.