Malonat-semialdehid dehidrogenaza (acetilacija)
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| Malonat-semialdehid dehidrogenaza (acetilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.18 | ||||||||
| CAS broj | 9028-97-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Malonat-semialdehid dehidrogenaza (acetilacija) (EC 1.2.1.18, malonska semialdehidna oksidativna dekarboksilaza) je enzim sa sistematskim imenom 3-oksopropanoat:NAD(P)+ oksidoreduktaza (dekarboksilacija, KoA-acetilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-oksopropanoat + KoA + NAD(P)+ acetil-KoA + CO2 + NAD(P)H
Reference[uredi | uredi kod]
- ↑ Hayaishi, O., Nishizuka, Y., Tatibana, M., Takeshita, M. and Kuno, S. (1961). „Enzymatic studies on the metabolism of β-alanine”. J. Biol. Chem. 236: 781-790. PMID 13712439.
- ↑ Jakoby, W.B. (1963). „Aldehyde dehydrogenases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 7 (2nd izd.). New York: Academic Press. str. 203-221.
- ↑ Yamada, E.W. and Jakoby, W.B. (1960). „Aldehyde oxidation. V. Direct conversion of malonic semialdehyde to acetyl-coenzyme A”. J. Biol. Chem. 235: 589-594. PMID 13846369.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.