Leukotrienska C4 hidrolaza
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Leukotrienska C4 hidrolaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.19.14 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Leukotrienska C4 hidrolaza (EC 3.4.19.14, gama-glutamilna leukotrienaza, GGT5) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- leukotrien C4 + H2O leukotrien D4 + L-glutamat
Ovaj mišji enzim je specifičan za leukotrien C4.
Reference[uredi | uredi kod]
- ↑ Carter, B.Z., Wiseman, A.L., Orkiszewski, R., Ballard, K.D., Ou, C.N. and Lieberman, M.W. (1997). „Metabolism of leukotriene C4 in γ-glutamyl transpeptidase-deficient mice”. J. Biol. Chem. 272: 12305-12310. PMID 9139674.
- ↑ Shi, Z.Z., Han, B., Habib, G.M., Matzuk, M.M. and Lieberman, M.W. (2001). „Disruption of γ-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response”. Mol. Cell Biol. 21: 5389-5395. PMID 11463821.
- ↑ Han, B., Luo, G., Shi, Z.Z., Barrios, R., Atwood, D., Liu, W., Habib, G.M., Sifers, R.N., Corry, D.B. and Lieberman, M.W. (2002). „γ-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D4 formation in vivo”. Am J Pathol 161: 481-490. PMID 12163373.
- ↑ Wickham, S., West, M.B., Cook, P.F. and Hanigan, M.H. (2011). „Gamma-glutamyl compounds: substrate specificity of γ-glutamyl transpeptidase enzymes”. Anal. Biochem. 414: 208-214. PMID 21447318.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.