Latosterol oksidaza
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| Latosterol oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.21.6 | ||||||||
| CAS broj | 37255-37-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Latosterol oksidaza (EC 1.14.21.6, Delta7-sterol Delta5-dehidrogenaza, Delta7-sterol 5-desaturaza, Delta7-sterol-C5(6)-desaturaza, 5-DES) je enzim sa sistematskim imenom 5alfa-holest-7-en-3beta-ol,NAD(P)H:kiseonik 5-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5alfa-holest-7-en-3beta-ol + NAD(P)H + H+ + O2 holesta-5,7-dien-3beta-ol + NAD(P)+ + 2H2O
Ovaj enzim katalizuje uvođenje C5 dvostruke veze u B prsten Delta7-sterola čime nastaju korespondirajući Delta5,7-steroli kod sisara, kvasca i biljki.
Reference[uredi | uredi kod]
- ↑ Dempsey, M.E., Seaton, J.D., Schroepfer, G.J. and Trockman, R.W. (1964). „The intermediary role of Δ5,7-cholestadien-3β-ol in cholesterol biosynthesis”. J. Biol. Chem. 239: 1381-1387. PMID 14189869.
- ↑ Nishino, H., Nakaya, J., Nishi, S., Kurosawa, T. and Ishibashi, T. (1997). „Temperature-induced differential kinetic properties between an initial burst and the following steady state in membrane-bound enzymes: studies on lathosterol 5-desaturase”. Arch. Biochem. Biophys. 339: 298-304. PMID 9056262.
- ↑ Taton, M. and Rahier, A. (1996). „Plant sterol biosynthesis: identification and characterization of higher plant Δ7-sterol C5(6)-desaturase”. Arch. Biochem. Biophys. 325: 279-288. PMID 8561508.
- ↑ Taton, M., Husselstein, T., Benveniste, P. and Rahier, A. (2000). „Role of highly conserved residues in the reaction catalyzed by recombinant Δ7-sterol-C5(6)-desaturase studied by site-directed mutagenesis”. Biochemistry 39: 701-711. PMID 10651635.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.