Kinurenin

Izvor: Wikipedia
Kinurenin
L-Kynurenine.svg
IUPAC ime
Drugi nazivi (S)-Kinurenin
Identifikacija
CAS registarski broj 343-65-7, (D/L)
2922-83-0 (L)
13441-51-5 (D)
PubChem[1][2] 846
MeSH Kynurenine
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C10H12N2O3
Molarna masa 208.21 g mol−1



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

L-Kinurenin je metabolit aminokiseline L-triptofan[3] koji se koristi u produkciji niacina. Smatra se da posreduje pojavu tikova.[4][5]

Kinureninaza katabolizuje konverziju kinurenina u antranilnu kiselinu[6], dok kinurenin—oksoglutarat transaminaza katabolizuje njegovu konverziju u kinurensku kiselinu. Kinurenin 3-hidroksilaza konvertuje kinurenin do 3-hidroksikinurenina.[7]

Literatura[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Moroni F (June 1999). "Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites". European Journal of Pharmacology 375 (1-3): 87–100. PMID 10443567. 
  4. Hoekstra PJ, Anderson GM, Troost PW, Kallenberg CG, Minderaa RB (June 2007). "Plasma kynurenine and related measures in tic disorder patients". European Child & Adolescent Psychiatry. 16 Suppl 1: 71–7. doi:10.1007/s00787-007-1009-1. PMID 17665285. Retrieved 06. 04. 2011.. 
  5. "Kynurenine potentiates the DOI head shake in mice | DeepDyve - Research. Rent. Read.". http://www.deepdyve.com/lp/sage/kynurenine-potentiates-the-doi-head-shake-in-mice-VcC8uCOwXw. pristupljeno 06. 04. 2011.. 
  6. European Bioinformatics Institute. "Kynureninase,". http://www.ebi.ac.uk/interpro/IEntry?ac=IPR010111. 
  7. Saito, Y., Hayaishi, O., Rothberg, S. (1957). "Studies on oxygenases; enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine". J. Biol. Chem. 229 (2): 921–34. PMID 13502353. 

Spoljašnje veze[uredi - уреди]