Kinurenin

Izvor: Wikipedia
Kinurenin
L-Kynurenine.svg
IUPAC ime
Drugi nazivi (S)-Kinurenin
Identifikacija
CAS registarski broj 343-65-7, (D/L)
2922-83-0 (L)
13441-51-5 (D)
PubChem[1][2] 846
MeSH Kynurenine
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C10H12N2O3
Molarna masa 208.21 g mol−1



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

L-Kinurenin je metabolit aminokiseline L-triptofan[3] koji se koristi u produkciji niacina. Smatra se da posreduje pojavu tikova.[4][5]

Kinureninaza katabolizuje konverziju kinurenina u antranilnu kiselinu[6], dok kinurenin—oksoglutarat transaminaza katabolizuje njegovu konverziju u kinurensku kiselinu. Kinurenin 3-hidroksilaza konvertuje kinurenin do 3-hidroksikinurenina.[7]

Literatura[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Moroni F (June 1999). "Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites". European Journal of Pharmacology 375 (1-3): 87–100. PMID 10443567. pristupljeno na 06. 04. 2011.. 
  4. Hoekstra PJ, Anderson GM, Troost PW, Kallenberg CG, Minderaa RB (June 2007). "Plasma kynurenine and related measures in tic disorder patients". European Child & Adolescent Psychiatry 16 Suppl 1: 71–7. DOI:10.1007/s00787-007-1009-1. PMID 17665285. pristupljeno na 06. 04. 2011.. 
  5. "Kynurenine potentiates the DOI head shake in mice | DeepDyve - Research. Rent. Read.". http://www.deepdyve.com/lp/sage/kynurenine-potentiates-the-doi-head-shake-in-mice-VcC8uCOwXw. pristupljeno 06. 04. 2011.. 
  6. European Bioinformatics Institute. "Kynureninase,". http://www.ebi.ac.uk/interpro/IEntry?ac=IPR010111. 
  7. Saito, Y., Hayaishi, O., Rothberg, S. (1957). "Studies on oxygenases; enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine". J. Biol. Chem. 229 (2): 921–34. PMID 13502353. 

Spoljašnje veze[uredi - уреди]