Katehol O-metiltransferaza

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Katehol O-metiltransferaza
Catechol-O-methyl transferase 3bwm.png
Identifikatori
EC broj 2.1.1.6
CAS broj 9012-25-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Katehol O-metiltransferaza (EC 2.1.1.6, COMT I, COMT II, S-COMT, rastvorna forma katehol-O-metiltransferaze, MB-COMT, membranska forma katehol-O-metiltransferaze, kateholna metiltransferaza, kateholaminska O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:katehol O-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + katehol \rightleftharpoons S-adenozil-L-homocistein + gvajakol

Enzim sisara deluje brže na kateholamine kao što je adrenalin ili noradrenalin nego na katehole.

Reference[uredi - уреди]

  1. Axelrod, J. and Tomchick, R. (1958). "Enzymatic O-methylation of epinephrine and other catechols". J. Biol. Chem. 233: 702–705. PMID 13575440. 
  2. Gulliver, P.A. and Tipton, K.F. (1979). "The purification and properties of pig brain catechol-O-methyltransferase". J. Neurochem. 32: 1525–1529. PMID 438821. 
  3. Huh, M.M.O. and Friedhof, A.J. (1979). "Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization". J. Biol. Chem. 254: 299–308. PMID 762061. 

Literatura[uredi - уреди]

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