Karboksipeptidaza u

Izvor: Wikipedia
Karboksipeptidaza u
Identifikatori
EC broj 3.4.17.20
CAS broj 156621-18-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Karboksipeptidaza u (EC 3.4.17.20, argininska karboksipeptidaza, karboksipeptidaza R, plazmatična karboksipeptidaza B, trombinom aktivirani fibrinolizni inhibitor) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje C-terminalnog Arg i Lys sa polipeptida

Pro-karboksipeptidaza U se u (ljudskoj) plazmi aktivira trombinom ili plazminom tokom zgrušavanja, čime se formira nestabilna karboksipeptidaza U.

Reference[uredi - уреди]

  1. Eaton, D.L., Malloy, B.E., Tsai, S.P., Henzel, W. and Drayna, D. (1991). "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma". J. Biol. Chem. 266: 21833–21838. PMID 1939207. 
  2. Shinohara, T., Sakurada, C., Suzuki, T., Takeuchi, O., Campbell, W., Ikeda, S., Okada, N. and Okada, H. (1994). "Pro-carboxypeptidase R cleaves bradykinin following activation". Int. Arch. Allergy Immunol. 103: 400–404. PMID 8130654. 
  3. Wang, W., Hendriks, D.F. and Scharpé, S. (1994). "Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen". J. Biol. Chem. 269: 15937–15944. PMID 8195249. 
  4. Tan, A.K. and Eaton, D.L. (1995). "Activation and characterization of procarboxypeptidase B from human plasma". Biochemistry 34: 5811–5816. PMID 7727441. 
  5. Broze, G.J., Jr. and Higuchi, D.A. (1996). "Coagulation-dependent inhibition of fibrinolysis: Role of carboxypeptidase U and the premature lysis of clots from hemophilic plasma". Blood 88: 3815–3823. PMID 8916945. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]