I-karaginaza
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| I-karaginaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.157 | ||||||||
| CAS broj | 50936-37-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
I-karaginaza (EC 3.2.1.157, Iota-carrageenase) je enzim sa sistematskim imenom I-karaginan 4-beta-D-glikanohidrolaza (inverzija konfiguracije).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endohidroliza (1->4)-beta-D-veza između D-galaktoza 4-sulfata i 3,6-anhidro-D-galaktoza-2-sulfata u I-karaginanima
Glavni produkti hidrolize su neokaratetraoza sulfat i neokaraheksaoza sulfat.
Reference[uredi | uredi kod]
- ↑ Barbeyron, T., Michel, G., Potin, P., Henrissat, B. and Kloareg, B. (2000). „ι-Carrageenases constitute a novel family of glycoside hydrolases, unrelated to that of κ-carrageenases”. J. Biol. Chem. 275: 35499-35505. PMID 10934194.
- ↑ Michel, G., Chantalat, L., Fanchon, E., Henrissat, B., Kloareg, B. and Dideberg, O. (2001). „The ι-carrageenase of Alteromonas fortis. A β-helix fold-containing enzyme for the degradation of a highly polyanionic polysaccharide”. J. Biol. Chem. 276: 40202-40209. PMID 11493601.
- ↑ Michel, G., Helbert, W., Kahn, R., Dideberg, O. and Kloareg, B. (2003). „The structural bases of the processive degradation of ι-carrageenan, a main cell wall polysaccharide of red algae”. J. Mol. Biol. 334: 421-433. PMID 14623184.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.