Hinaldat 4-oksidoreduktaza
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| Hinaldat 4-oksidoreduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.18 | ||||||||
| CAS broj | 149885-77-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hinaldat 4-oksidoreduktaza (EC 1.3.99.18, hinaldinska kiselina 4-oksidoreduktaza) je enzim sa sistematskim imenom hinolin-2-karboksilat:akceptor 4-oksidoreduktaza (hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hinaldat + akceptor +H2O kinurenat + redukovani akceptor
Ovaj enzim iz Pseudomonas sp. takođe deluje na hinolin-8-karboksilat, dok enzim iz Serratia marcescens 2CC-1 oksiduje nikotinat. Hinaldat je supstrat oba enzima.
Reference[uredi | uredi kod]
- ↑ Sauter, M., Tshisuaka, B., Fetzner, S. and Lingens, F. (1993). „Microbial metabolism of quinoline and related compounds. XX. Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases”. Biol. Chem. Hoppe Seyler 374: 1037-1046. PMID 8292263.
- ↑ Fetzner, S. and Lingens, F. (1993). „Microbial metabolism of quinoline and related compounds. XVIII. Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1”. Biol. Chem. Hoppe-Seyler 374: 363-376. PMID 8357532.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.