Hidroliza rastvornog epoksida
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| Hidroliza rastvornog epoksida | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.3.2.10 | ||||||||
| CAS broj | 9048-63-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hidroliza rastvornog epoksida (EC 3.3.2.10, epoksidna hidraza, epoksidna hidrataza, aren-oksidna hidrataza, aril epoksidna hidraza, trans-stilben oksidna hidrolaza, sEH, citozol epoksidna hidrolaza) je enzim sa sistematskim imenom epoksidna hidrolaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim katalizuje hidrolizu trans-supstituisanih epoksida, poput trans-stilbene oksida, kao i raznih alifatičnih epoksida izvedenih iz metabolizma masnih kiselina.
Reference[uredi | uredi kod]
- ↑ Newman, J.W., Morisseau, C., Harris, T.R. and Hammock, B.D. (2003). „The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity”. Proc. Natl. Acad. Sci. USA 100: 1558-1563. PMID 12574510.
- ↑ Cronin, A., Mowbray, S., Dürk, H., Homburg, S., Fleming, I., Fisslthaler, B., Oesch, F. and Arand, M. (2003). „The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase”. Proc. Natl. Acad. Sci. USA 100: 1552-1557. PMID 12574508.
- ↑ Oesch, F. (1973). „Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds”. Xenobiotica 3: 305-340. PMID 4584115.
- ↑ Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles”. Annu. Rev. Pharmacol. Toxicol. 45: 311-333. PMID 15822179.
- ↑ Yu, Z., Xu, F., Huse, L.M., Morisseau, C., Draper, A.J., Newman, J.W., Parker, C., Graham, L., Engler, M.M., Hammock, B.D., Zeldin, D.C. and Kroetz, D.L. (2000). „Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids”. Circ. Res. 87: 992-998. PMID 11090543.
- ↑ Lacourciere, G.M. and Armstrong, R.N. (1993). „The catalytic mechanism of microsomal epoxide hydrolase involves an ester intermediate”. J. Am. Chem. Soc. 115: 10466-10456.
- ↑ Fretland, A.J. and Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41-59. PMID 11154734.
- ↑ Zeldin, D.C., Wei, S., Falck, J.R., Hammock, B.D., Snapper, J.R. and Capdevila, J.H. (1995). „Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis”. Arch. Biochem. Biophys. 316: 443-451. PMID 7840649.
- ↑ Haeggström, J., Meijer, J. and Rådmark, O. (1986). „Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase”. J. Biol. Chem. 261: 6332-6337. PMID 3009453.
- ↑ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1-51. PMID 15748653.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.