Hepsin
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| Hepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.106 | ||||||||
| CAS broj | 112398-23-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hepsin (EC 3.4.21.106) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje nakon baznih aminokiselinskih ostataka, sa jakom preferencijom za Arg u odnosu na Lys
Ova membrana serinska peptidaza učestvuje u ćelijskom rastu i razvoju.
Reference[uredi | uredi kod]
- ↑ Zhukov, A., Hellman, U. and Ingelman-Sundberg, M. (1997). „Purification and characterization of hepsin from rat liver microsomes”. Biochim. Biophys. Acta 1337: 85-95. PMID 9003440.
- ↑ Kazama, Y., Hamamoto, T., Foster, D.C. and Kisiel, W. (1995). „Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation”. J. Biol. Chem. 270: 66-72. PMID 7814421.
- ↑ Torres-Rosado, A., O'Shea, K.S., Tsuji, A., Chou, S.H. and Kurachi, K. (1993). „Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth”. Proc. Natl. Acad. Sci. USA 90: 7181-7185. PMID 8346233.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.