Heparan-a-glukozaminid N-acetiltransferaza
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| Heparan-a-glukozaminid N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.78 | ||||||||
| CAS broj | 79955-83-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Heparan-a-glukozaminid N-acetiltransferaza (EC 2.3.1.78, acetil-KoA:alfa-glucosaminide N-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:heparan-alfa-D-glukozaminid N-acetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + heparan sulfate α-D-glukozaminid = KoA + heparan sulfat N-acetil-α-D-glukozaminid
Ovaj enzim acetilatiluje glukozaminske grupe heparan sulfata i heparina sa kojih je uklonjen sulfat. Takođe deluje na heparin.
Reference[uredi | uredi kod]
- ↑ Klein, V., Kresse, H. and von Figura, K. (1978). „Sanfilippo syndrome type C: deficiency of acetyl-CoA:α-glucosaminide N-acetyltransferase in skin fibroblasts”. Proc. Natl. Acad. Sci. USA 75: 5185-5189. PMID 33384.
- ↑ Pohlmann, R., Klein, U., Fromme, H.G. and von Figura, K. (1981). „Localisation of acetyl-CoA: α-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver”. Hoppe-Seyler's Z. Physiol. Chem. 362: 1199-1207. PMID 7346380.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.